CAS 387-79-1|17a-Hydroxypregnenolone
Introduction：Basic information about CAS 387-79-1|17a-Hydroxypregnenolone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 17a-Hydroxypregnenolone | ||
|---|---|---|---|
| CAS Number | 387-79-1 | Molecular Weight | 334.493 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 468.1±40.0 °C at 760 mmHg |
| Molecular Formula | C21H32O3 | Melting Point | 273℃ |
| MSDS | ChineseUSA | Flash Point | 251.0±23.8 °C |
| Symbol | GHS02, GHS06, GHS08 | Signal Word | Danger |
Names
| Name | 17α-hydroxypregnenolone |
|---|---|
| Synonym | More Synonyms |
17a-Hydroxypregnenolone BiologicalActivity
| Description | 17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA). |
|---|---|
| Related Catalog | Research Areas >>Endocrinology |
| Target | Human Endogenous Metabolite |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 468.1±40.0 °C at 760 mmHg |
| Melting Point | 273℃ |
| Molecular Formula | C21H32O3 |
| Molecular Weight | 334.493 |
| Flash Point | 251.0±23.8 °C |
| Exact Mass | 334.250793 |
| PSA | 57.53000 |
| LogP | 3.46 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.540 |
| InChIKey | JERGUCIJOXJXHF-TVWVXWENSA-N |
| SMILES | CC(=O)C1(O)CCC2C3CC=C4CC(O)CCC4(C)C3CCC21C |
| Storage condition | ?20°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 99600 ug/kg
- SEX/DURATION :
- male 48 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- REFERENCE :
- IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 5,45,1967
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 96 mg/kg
- SEX/DURATION :
- male 48 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
- REFERENCE :
- IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 11,484,1973
Safety Information
| Symbol | GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | F,T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol |
| WGK Germany | 3 |
| RTECS | TU5548000 |
Articles26
More Articles| Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR. J. Biol. Chem. 288(23) , 17008-18, (2013) The membrane heme protein cytochrome b5 (b5) can enhance, inhibit, or have no effect on cytochrome P450 (P450) catalysis, depending on the specific P450, substrate, and reaction conditions, but the st... | |
| Serum concentrations of adrenal steroids and their precursors as a measure of maturity of adrenocortical function in very premature newborns. Horm. Res. Paediatr. 74(5) , 358-64, (2010) Relative adrenocortical insufficiency is often seen in sick premature newborns. As the human fetal adrenal cortex does not express the 3β-hydroxysteroid dehydrogenase (3β-HSD) enzyme before about 23 w... | |
| Clinicopathological features, biochemical and molecular markers in 5 patients with adrenocortical carcinoma. Endocr. J. 58(7) , 527-34, (2011) Adrenocortical carcinoma (ACC) is a very rare malignant tumor with poor prognosis. To gain insight into the pathogenic significance of ACC, we studied clinicopathological features and gene expression ... |
Synonyms
| MFCD00021129 |
| Pregnan-2-one, 3,17-dihydroxy- |
| Hydroxypregnenolone |
| EINECS 206-862-6 |
| HYDROXYPREGNENOLONE,17A |
| 17a-Hydroxypregnolone |
| 17alpha-Hydroxy |
| 5-Pregnen-3.β.,17.α.-diol-20-one |
| 17-OH PREG |
| 3,17-Dihydroxypregnan-2-one |
| 17-OH-pregnenolone |
| 17A-HYDROXY PREGNENOLONE |
| 17alpha-hydroxypregnenolone |
| 17-Hydroxy Pregnenolone |
| 17A-HYDROXYPREGENOLONE |
