CAS 145224-92-6|Sodium deoxycholate monohydrate
Introduction：Basic information about CAS 145224-92-6|Sodium deoxycholate monohydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sodium deoxycholate monohydrate | ||
|---|---|---|---|
| CAS Number | 145224-92-6 | Molecular Weight | 432.56900 |
| Density | / | Boiling Point | 581.5ºC at 760mmHg |
| Molecular Formula | C24H41NaO5 | Melting Point | >300ºC |
| MSDS | ChineseUSA | Flash Point | 319.5ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Sodium Deoxycholate Monohydrate |
|---|---|
| Synonym | More Synonyms |
Sodium deoxycholate monohydrate BiologicalActivity
| Description | Deoxycholic acid (cholanoic acid) sodium hydrate，a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>GPCR19Research Areas >>Metabolic Disease |
| Target | Microbial Metabolite |
| In Vitro | Deoxycholic acid sodium hydrate (DCA) (100 μM) induces the production of gastric cancer cell line MGC803 resistant to acidified bile acids and enhances their survival and proliferation activity under bile acid stress[2]. Deoxycholic acid sodium hydrate (DCA) (100 μM)-induced resistant cells shows altered morphology, significantly elevated telomerase activity, better cell viability and reduces apoptosis compared to normal MGC803 cells[2]. |
| References | [1]. Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809. [2]. Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797. |
Chemical & Physical Properties
| Boiling Point | 581.5ºC at 760mmHg |
|---|---|
| Melting Point | >300ºC |
| Molecular Formula | C24H41NaO5 |
| Molecular Weight | 432.56900 |
| Flash Point | 319.5ºC |
| Exact Mass | 432.28500 |
| PSA | 89.82000 |
| LogP | 3.07890 |
| InChIKey | HKLBTQUQYACMJN-WTCAICSISA-N |
| SMILES | CC(CCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C.O.[Na] |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H335 |
| Precautionary Statements | P261 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | R22;R37 |
| Safety Phrases | S22-S26-S36/37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3.0 |
Articles4
More Articles| Dissolution of gall-stones in vitro. J. Indian Med. Assoc. 89 , 129, (1991) An in vitro study on dissolution of 36 gall-stones obtained from 3 patients (12 stones from each patient) was carried out in heparin, bile salt and clofibrate solutions of different strengths. Heparin... | |
| Immobilization of lipoxygenase in an alginate-silicate solgel matrix: formation of fatty acid hydroperoxides Hsu, A., et al. Biotechnol. Lett. 19 , 71, (1997) | |
| Liquid crystals and phase equilibria binary bile salt-water systems. Marques EF, et al. Langmuir 16(11) , 5178-5186, (2000) |
Synonyms
| MFCD00150750 |
| EINECS 206-132-7 |
| Sodium deoxycholate monohydrate |
| sodium,(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate,hydrate |
| DEOXYCHOLIC ACID SODIUM SALT MONOHYDRATE |
