CAS 87691-27-8|N-BOC-cis-4-Hydroxy-L-proline

Introduction:Basic information about CAS 87691-27-8|N-BOC-cis-4-Hydroxy-L-proline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameN-BOC-cis-4-Hydroxy-L-proline
CAS Number87691-27-8Molecular Weight231.246
Density1.3±0.1 g/cm3Boiling Point390.9±42.0 °C at 760 mmHg
Molecular FormulaC10H17NO5Melting Point146ºC
MSDSUSAFlash Point190.2±27.9 °C
Symbol
GHS07, GHS09
Signal WordWarning

Names

NameN-BOC-cis-4-Hydroxy-L-proline
SynonymMore Synonyms

N-BOC-cis-4-Hydroxy-L-proline BiologicalActivity

DescriptionN-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2
Related CatalogResearch Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker
Target

Non-cleavable

In VitroADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

Density1.3±0.1 g/cm3
Boiling Point390.9±42.0 °C at 760 mmHg
Melting Point146ºC
Molecular FormulaC10H17NO5
Molecular Weight231.246
Flash Point190.2±27.9 °C
Exact Mass231.110672
PSA87.07000
LogP-0.71
Vapour Pressure0.0±2.0 mmHg at 25°C
Index of Refraction1.531
InChIKeyBENKAPCDIOILGV-BQBZGAKWSA-N
SMILESCC(C)(C)OC(=O)N1CC(O)CC1C(=O)O

Safety Information

Symbol
GHS07, GHS09
Signal WordWarning
Hazard StatementsH315-H319-H335-H400
Precautionary StatementsP261-P273-P305 + P351 + P338
Personal Protective Equipmentdust mask type N95 (US);Eyeshields;Gloves
Hazard CodesXi:Irritant;N:Dangerousfortheenvironment;
Risk PhrasesR36/37/38;R50
Safety PhrasesS26-S36/37-S60-S61
RIDADRUN 3077 9 / PGIII
WGK Germany3
HS Code2933990090

Customs

HS Code2933990090
Summary2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S,4S)-
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S,4R)-
(4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline
MFCD02094406
Boc-(2S,4S)-(-)-4-hydroxypyrrolidine-2-carboxylic acid
(4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline
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