Introduction：Basic information about CAS 147266-92-0|N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline |
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| CAS Number | 147266-92-0 | Molecular Weight | 231.246 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 390.9±42.0 °C at 760 mmHg |
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| Molecular Formula | C10H17NO5 | Melting Point | 123ºC |
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| MSDS | ChineseUSA | Flash Point | 190.2±27.9 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | (2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 390.9±42.0 °C at 760 mmHg |
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| Melting Point | 123ºC |
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| Molecular Formula | C10H17NO5 |
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| Molecular Weight | 231.246 |
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| Flash Point | 190.2±27.9 °C |
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| Exact Mass | 231.110672 |
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| PSA | 87.07000 |
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| LogP | -0.71 |
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| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
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| Index of Refraction | 1.531 |
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| InChIKey | BENKAPCDIOILGV-NKWVEPMBSA-N |
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| SMILES | CC(C)(C)OC(=O)N1CC(O)CC1C(=O)O |
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| Storage condition | 2-8°C |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H319 |
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| Precautionary Statements | P305 + P351 + P338 |
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| Hazard Codes | Xi |
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| Risk Phrases | 36 |
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| Safety Phrases | 26 |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| (4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline |
| Boc-trans-4-Hydroxy-D-proline |
| 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2R,4S)- |
| N-Boc-trans-4-hydroxy-D-proline |
| MFCD01861341 |
