Introduction：Basic information about CAS 911-40-0|7-Keto-3α,12-α-dihydroxycholanic Acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 7-Keto-3α,12-α-dihydroxycholanic Acid |
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| CAS Number | 911-40-0 | Molecular Weight | 406.55600 |
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| Density | 1.18g/cm3 | Boiling Point | 583ºC at 760mmHg |
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| Molecular Formula | C24H38O5 | Melting Point | 54-60ºC |
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| MSDS | / | Flash Point | 320.4ºC |
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Names
| Name | 3α,12α-dihydroxy-7-oxo-5β-cholanic acid |
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| Synonym | More Synonyms |
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7-Keto-3α,12-α-dihydroxycholanic Acid BiologicalActivity
| Description | 7-keto-lithocholic acid is a metabolite of bile acids in Clostridium absonum. 7-keto-lithocholic acid is also converted from Lactobacillus and Bifidobacterium with specific condition[1][2]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| In Vitro | 7-keto-lithocholic acid shows an increasing bioconversion rate with addition of an equimolar concentration of deoxycholic acid (which itself is not metabolized)[1]. 7-keto-lithocholic acid is induced by deoxycholic acid and then it's metabolized[1]. E. lentum-like c-25 converts 81.7% of 2 mM cholic acid to deoxycholic acid and 3.7% to 7-keto-deoxycholic acid under anaerobic incubation[2]. E. lentum-like c-25 converts 91.5% of 150 mg/mL cholic acid to deoxycholic acid and 1.1% to 7-keto-deoxycholic acid under anaerobic incubation[2]. |
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| References | [1]. Sutherland JD, et al. The metabolism of primary, 7-oxo, and 7 beta-hydroxy bile acids by Clostridium absonum. J Lipid Res. 1982 Jul;23(5):726-32. [2]. Takahashi T, et al. Absence of cholic acid 7 alpha-dehydroxylase activity in the strains of Lactobacillus and Bifidobacterium. J Dairy Sci. 1994 Nov;77(11):3275-86. |
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Chemical & Physical Properties
| Density | 1.18g/cm3 |
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| Boiling Point | 583ºC at 760mmHg |
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| Melting Point | 54-60ºC |
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| Molecular Formula | C24H38O5 |
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| Molecular Weight | 406.55600 |
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| Flash Point | 320.4ºC |
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| Exact Mass | 406.27200 |
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| PSA | 94.83000 |
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| LogP | 3.65690 |
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| Index of Refraction | 1.55 |
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| InChIKey | RHCPKKNRWFXMAT-RRWYKFPJSA-N |
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| SMILES | CC(CCC(=O)O)C1CCC2C3C(=O)CC4CC(O)CCC4(C)C3CC(O)C12C |
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Safety Information
Synonyms
| (3alpha,5beta,12alpha)-3,12-Dihydroxy-7-oxocholan-24-oic acid |
| 7-Ketodeoxycholic acid |
| 7-ketodeoxycholate |
| (4R)-4-[(3R,5S,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid |
| 7-oxodeoxycholate |
| 3alpha,12alpha-Diol-7-one-5beta-cholanoic acid |
| 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholan-24-oic Acid |
| 7-Oxodeoxycholic acid |
| 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanic acid |
| 3a,12a-dihydroxy-7-oxo-5b-cholan-24-oic acid |
| 7-Keto-3α,12-α-dihydroxycholanic Acid |
