CAS 67287-39-2|SKF 81297 hydrobromide

Introduction：Basic information about CAS 67287-39-2|SKF 81297 hydrobromide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. SKF 81297 hydrobromide BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	SKF 81297 hydrobromide
CAS Number	67287-39-2	Molecular Weight	370.669
Density	/	Boiling Point	/
Molecular Formula	C₁₆H₁₇BrClNO₂	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	(R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide
Synonym	More Synonyms

SKF 81297 hydrobromide BiologicalActivity

Description	SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist[1].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease
Target	D1 Receptor
In Vivo	SKF 81297 hydrobromide (0.05-0.3 mg/kg，肌注，一次) 刺激 MPTP 损伤猴子的运动行为[1]。 Animal Model: Four male rhesus monkeys (Macaca mulatta, 7.0-11.3 kg)[1] Dosage: 0.05-0.3 mg/kg Administration: Injected intramuscularly (i.m.), once Result: Significantly increased rotational behaviour and right-sided hand use in unilateral MPTP-lesioned rhesus monkeys.
References	[1]. Vermeulen RJ, et al. The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys. Eur J Pharmacol. 1993 Apr 22;235(1):143-7. [2]. Auger ML, et al. Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF-81297 and d-Govadine. Neuropharmacology. 2020 Jan 1;162:107844.

Chemical & Physical Properties

Molecular Formula	C₁₆H₁₇BrClNO₂
Molecular Weight	370.669
Exact Mass	369.013123
PSA	52.49000
LogP	4.31570
InChIKey	RMIJGBMRNYUZRG-UHFFFAOYSA-N
SMILES	Br.Oc1cc2c(c(Cl)c1O)CCNCC2c1ccccc1

Safety Information

WGK Germany	3
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE

1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-, (1R)-, hydrobromide (1:1)

R-(+)-SKF-81297 hydrobromide

(±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrobromide (1:1)

6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

(1R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrobromide (1:1)

Metastin (human)

(R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide

1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-, hydrobromide (1:1)

(+/-)-6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrobromide

Recommended......