Introduction：Basic information about CAS 149965-92-4|5-Fluorouridine 5'-O-β-D-galactopyranoside, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5-Fluorouridine 5'-O-β-D-galactopyranoside |
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| CAS Number | 149965-92-4 | Molecular Weight | 424.33200 |
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| Density | 1.815g/cm3 | Boiling Point | / |
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| Molecular Formula | C15H21FN2O11 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 5-Fluorouridine-5'-O-b-D-galactopyranoside |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | 5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is a 5-Fluorouridine prodrug. 5-Fluorouridine 5'-O-β-D-galactopyranoside can be converted by the enzyme β-D-galactosidase to the potent antineoplastic agent 5-Fluorouridine[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| In Vitro | The ratio of the IC50 of 5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) to that of 5-Fluorouridine determined on a variety of tumor cell lines in vitro ranged from 500:1-1000:1[1]. |
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| In Vivo | 5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is more than 100x less toxic than 5-Fluorouridine to bone marrow cells in Balb/c mice[1]. |
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| References | [1]. R Abraham, et al. Conjugates of COL-1 monoclonal antibody and beta-D-galactosidase can specifically kill tumor cells by generation of 5-fluorouridine from the prodrug beta-D-galactosyl-5-fluorouridine. Cell Biophys. 1994;24-25:127-33. |
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Chemical & Physical Properties
| Density | 1.815g/cm3 |
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| Molecular Formula | C15H21FN2O11 |
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| Molecular Weight | 424.33200 |
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| Exact Mass | 424.11300 |
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| PSA | 203.93000 |
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| Index of Refraction | 1.668 |
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| InChIKey | BTPARJRXLUUYJW-FQKYAJAOSA-N |
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| SMILES | O=c1[nH]c(=O)n(C2OC(COC3OC(CO)C(O)C(O)C3O)C(O)C2O)cc1F |
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Synonyms
