Introduction：Basic information about CAS 150145-89-4|(S)-MCPG, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (S)-MCPG |
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| CAS Number | 150145-89-4 | Molecular Weight | 209.19900 |
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| Density | / | Boiling Point | 425.3ºC at 760mmHg |
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| Molecular Formula | C10H11NO4 | Melting Point | / |
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| MSDS | USA | Flash Point | 211ºC |
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Names
| Name | (s)-alpha-methyl-4-carboxyphenylglycine |
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| Synonym | More Synonyms |
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(S)-MCPG BiologicalActivity
| Description | (S)-MCPG is the active isomer of (RS)-MCPG (Cat. No. HY-100371), non-selective group I/group II metabotropic glutamate receptor antagonist. In vivo: (S)-MCPG (20.8 μg) injected intraventricularly (i.c.v.) before testing impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not. Memory retention, evaluated 24 hr post-training, is also affected by the high dose of MCPG. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>mGluRResearch Areas >>Neurological Disease |
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| References | [1]. Bordi F et al. Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology. 1996;35(11):1557-65. [2]. Sekiyama N et al. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br J Pharmacol. 1996 Apr;117(7):1493-503. [3]. Jane DE et al. Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones. Neuropharmacology. 1993 Jul;32(7):725-7. |
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Chemical & Physical Properties
| Boiling Point | 425.3ºC at 760mmHg |
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| Molecular Formula | C10H11NO4 |
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| Molecular Weight | 209.19900 |
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| Flash Point | 211ºC |
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| Exact Mass | 209.06900 |
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| PSA | 100.62000 |
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| LogP | 1.34360 |
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| Vapour Pressure | 5.44E-08mmHg at 25°C |
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| InChIKey | DNCAZYRLRMTVSF-JTQLQIEISA-N |
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| SMILES | CC(N)(C(=O)O)c1ccc(C(=O)O)cc1 |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | S24/25 |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2922499990 |
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Customs
| HS Code | 2922499990 |
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| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
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Articles2
More Articles
| Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones. Neuropharmacology 32 , 725, (1993) The (+)-enantiomer of alpha-methyl-4-carboxyphenylglycine (MCPG) stereoslectively antagonized the depolarization of neonatal rat motoneurones and the excitation of rat thalamic neurons induced by the ... | |
| Inhibition of long-term potentiation in the dentate gyrus of freely moving rats by the metabotropic glutamate receptor antagonist MCPG. J. Neurosci. 15 , 87-98, (1995) Metabotropic glutamate receptors (mGluRs) are critically involved in the maintenance of long-term potentiation (LTP) (Reymann and Matthies, 1989; Behnisch et al., 1991; Izumi et al., 1991; Bashir et a... | |
Synonyms
| (+)-MCPG |
| (S)-alpha-Methyl-4-carboxyphenylglycine |
| 4-[(1S)-1-amino-1-carboxyethyl]benzoic acid |
| (S)-MCPG |
