CAS 153504-81-5|Licostinel
Introduction：Basic information about CAS 153504-81-5|Licostinel, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Licostinel | ||
|---|---|---|---|
| CAS Number | 153504-81-5 | Molecular Weight | 276.03 |
| Density | 1.757g/cm3 | Boiling Point | / |
| Molecular Formula | C8H3Cl2N3O4 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | 6,7-dichloro-5-nitro-1,4-dihydroquinoxaline-2,3-dione |
|---|---|
| Synonym | More Synonyms |
Licostinel BiologicalActivity
| Description | Licostinel (ACEA-1021) is a glycine receptor antagonist (IC50: 59 nM). Licostinel has neuroprotective activity[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| Target | 59 nM (glycine receptor)[1] |
| References | [1]. Zhou ZL, et al. Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists. Bioorg Med Chem. 2003 Apr 17;11(8):1769-80. [2]. Albers GW, et al. Dose escalation study of the NMDA glycine-site antagonist licostinel in acute ischemic stroke. Stroke. 1999 Mar;30(3):508-13. [3]. Martin H, et al. Effects of glycine receptor antagonism on spreading depression in the rat. Neurosci Lett. 1994 Oct 24;180(2):285-9. |
Chemical & Physical Properties
| Density | 1.757g/cm3 |
|---|---|
| Molecular Formula | C8H3Cl2N3O4 |
| Molecular Weight | 276.03 |
| Exact Mass | 274.95000 |
| PSA | 111.54000 |
| LogP | 1.95460 |
| Index of Refraction | 1.647 |
| InChIKey | CHFSOFHQIZKQCR-UHFFFAOYSA-N |
| SMILES | O=c1[nH]c2cc(Cl)c(Cl)c([N+](=O)[O-])c2[nH]c1=O |
Synonyms
| 6,7-Dichloro-5-nitro-2,3-quinoxalinedione |
| Licostinel |
| 5-Nitro-6,7-dichloro-2,3-quinoxalinedione |
| 2,3-Quinoxalinedione,6,7-dichloro-1,4-dihydro-5-nitro |
| 5-nitro-6,7-dichloro-1,4-dihydroquinoxaline-2,3-dione |
| ACEA-1021 |
| 6,7-dichloro-1,4-dihydro-8-nitro-2,3-quinoxalinedione |
| 1,4-dihydro-6,7-dichloro-5-nitroquinoxalin-2,3-dione |
| 6,7-Dichloro-1,4-dihydro-5-nitro-2,3-quinoxalinedione |
