CAS 155229-75-7|(3R,5S)-Fluvastatin
Introduction：Basic information about CAS 155229-75-7|(3R,5S)-Fluvastatin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (3R,5S)-Fluvastatin | ||
|---|---|---|---|
| CAS Number | 155229-75-7 | Molecular Weight | 433.44800 |
| Density | 1.23 | Boiling Point | 681.8ºC at 760 mmHg |
| Molecular Formula | C24H26FNO4 | Melting Point | / |
| MSDS | / | Flash Point | 366.1ºC |
Names
| Name | (+)-3r,5s-fluvastatin sodium salt |
|---|
(3R,5S)-Fluvastatin BiologicalActivity
| Description | (3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>HMG-CoA Reductase (HMGCR)Signaling Pathways >>Autophagy >>Autophagy |
| References | [1]. Araújo FA, Rocha MA, Capettini LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24. [2]. Makabe S, Takahashi Y, Watanabe H, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84. [3]. Scripture CD, Pieper JA. Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81. |
Chemical & Physical Properties
| Density | 1.23 |
|---|---|
| Boiling Point | 681.8ºC at 760 mmHg |
| Molecular Formula | C24H26FNO4 |
| Molecular Weight | 433.44800 |
| Flash Point | 366.1ºC |
| Exact Mass | 433.16700 |
| PSA | 85.52000 |
| LogP | 3.29340 |
