Introduction：Basic information about CAS 55511-44-9|D-Aminoglutethimide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | D-Aminoglutethimide |
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| CAS Number | 55511-44-9 | Molecular Weight | 232.27800 |
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| Density | 1.173g/cm3 | Boiling Point | 457.4ºC at 760 mmHg |
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| Molecular Formula | C13H16N2O2 | Melting Point | 115.5-119.5ºC(lit.) |
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| MSDS | USA | Flash Point | 230.4ºC |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | (R)-aminoglutethimide |
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| Synonym | More Synonyms |
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D-Aminoglutethimide BiologicalActivity
| Description | (R)-(+)-Aminoglutethimide is a potent and orally active aromatase inhibitor. (R)-(+)-Aminoglutethimide has the potential for the research of breast cancer[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Aromatase |
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| In Vivo | (R)-(+)-Aminoglutethimide (5, 50 mg/kg; p.o.) eliminates within 48 hr into urine and feces, mostly in the form of metabolites[2]. (R)-(+)-Aminoglutethimide (1, 10, 50 mg/kg; i.p.; 60 min before training) dose not induce any significant effect in 1 and 10 mg/kg, induces a loss of retention at 50 mg/kg in day-old chicks[3]. |
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| References | [1]. Dai Sig Im, et al. Chemo-enzymatic synthesis of (R)-(+)-aminoglutethimide by kinetic resolution of (±)-4-cyano-4-phenyl-1-hexanol. Journal of Molecular Catalysis B: Enzymatic. 2003, 26:185–191. [2]. Egger H, Bartlett F, Itterly W, Rodebaugh R, Shimanskas C. Metabolism of aminoglutethimide in the rat. Drug Metab Dispos. 1982 Jul-Aug;10(4):405-12. |
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Chemical & Physical Properties
| Density | 1.173g/cm3 |
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| Boiling Point | 457.4ºC at 760 mmHg |
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| Melting Point | 115.5-119.5ºC(lit.) |
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| Molecular Formula | C13H16N2O2 |
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| Molecular Weight | 232.27800 |
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| Flash Point | 230.4ºC |
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| Exact Mass | 232.12100 |
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| PSA | 72.19000 |
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| LogP | 1.73730 |
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| Index of Refraction | 1.566 |
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| InChIKey | ROBVIMPUHSLWNV-CYBMUJFWSA-N |
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| SMILES | CCC1(c2ccc(N)cc2)CCC(=O)NC1=O |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | 26-36 |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| (3R)-3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione |
| Aminoglutethimide,d |
| MFCD03094025 |
