CAS 55750-06-6|Imidocarb dipropionate
| Common Name | Imidocarb dipropionate | ||
|---|---|---|---|
| CAS Number | 55750-06-6 | Molecular Weight | 496.559 |
| Density | 1.39g/cm3 | Boiling Point | / |
| Molecular Formula | C25H32N6O5 | Melting Point | 205ºC |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 1,3-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea,propanoic acid |
|---|---|
| Synonym | More Synonyms |
Imidocarb dipropionate BiologicalActivity
| Description | Imidocarb dipropionate is a potent antiprotozoal agent. Imidocarb dipropionate is active against the parasite B. bovis with an IC50 of 87 μg/mL[1]. |
|---|---|
| Related Catalog | Research Areas >>Infection |
| Target | IC50: 87 μg/mL (Parasite B. bovis)[1] |
| In Vivo | Imidocarb dipropionate is administered by subcutaneous or intramuscular injection to horses (3.4 mg/kg bw) and cattle (2.I mg/kg bw). In horses, up to 4 doses may be given at 72-hour intervals. A second dose may be given 2 weeks after the first[1]. Imidocarb dipropionate is also used in sheep (1. 2mg/kg bw) for the treatment of babesiosis and anaplasmosis[1]. The acute oral LD50 value of Imidocarb dipropionate is in the range of 646 to 723 mg/kg bw in mice[1]. The acute oral LD50 value of Imidocarb is in the range of 454 to 1251 mg/kg bw in rats[1]. |
| References | [1]. Rodriguez RI, et al. In vitro responsiveness of Babesia bovis to Imidocarb dipropionate and the selection of a drug-adapted line. Vet Parasitol. 1996 Mar;62(1-2):35-41. |
Chemical & Physical Properties
| Density | 1.39g/cm3 |
|---|---|
| Melting Point | 205ºC |
| Molecular Formula | C25H32N6O5 |
| Molecular Weight | 496.559 |
| Exact Mass | 496.243408 |
| PSA | 164.51000 |
| LogP | 2.66700 |
| InChIKey | AFGQXWSHYUHHNV-UHFFFAOYSA-N |
| SMILES | CCC(=O)O.CCC(=O)O.O=C(Nc1cccc(C2=NCCN2)c1)Nc1cccc(C2=NCCN2)c1 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles29
More Articles| Comparison of glycopyrrolate and atropine in ameliorating the adverse effects of imidocarb dipropionate in horses. Equine Vet. J. 45(5) , 625-9, (2013) Imidocarb, an effective treatment for piroplasmosis, may cause colic and diarrhoea in horses. Atropine and glycopyrrolate are anticholinergics that could reduce the adverse effects of imidocarb. Howev... | |
| Failure of combination therapy with imidocarb dipropionate and toltrazuril to clear Hepatozoon canis infection in dogs. Parasitol. Res. 109(3) , 919-26, (2011) Current treatments with imidocarb dipropionate for infected dogs with Hepatozoon canis do not always provide parasitological cure. The objective of this study is to determine whether concomitant use o... | |
| Alterations in some blood coagulation parameters in naturally occurring cases of canine babesiosis. Acta Vet. Hung. 57(2) , 295-304, (2009) Changes in coagulation parameters were studied in dogs naturally infected with Babesia canis canis (n = 30), and haemostasis was evaluated and compared to values obtained from healthy dogs (n = 29). T... |
Synonyms
| MFCD00013161 |
| Imizol |
| Imidocarb Dipropionate |
| Propanoic acid - 1,3-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea (2:1) |
| Propanoic acid, compd. with urea, N,N'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]- (2:1) |
| EINECS 259-791-8 |
