Introduction：Basic information about CAS 11041-94-4|Higenamine HCl, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Higenamine HCl |
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| CAS Number | 11041-94-4 | Molecular Weight | 307.772 |
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| Density | / | Boiling Point | 522.4ºC at 760 mmHg |
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| Molecular Formula | C16H18ClNO3 | Melting Point | / |
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| MSDS | / | Flash Point | 209.6ºC |
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Names
| Name | 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydro chloride (1:1) |
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| Synonym | More Synonyms |
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Higenamine HCl BiologicalActivity
| Description | Higenamine hydrochloride (Norcoclaurine hydrochloride), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine hydrochloride (Norcoclaurine hydrochloride) has anti-apoptotic effects[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Endocrinology |
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| Target | β2-AR[1] |
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| References | [1]. Wu MP, et al. Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 2016 Feb;104:115-23. [2]. Lee SR, et al. Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acidsand energy expenditure in human subjects. Lipids Health Dis. 2013 Oct 21;12:148. |
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Chemical & Physical Properties
| Boiling Point | 522.4ºC at 760 mmHg |
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| Molecular Formula | C16H18ClNO3 |
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| Molecular Weight | 307.772 |
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| Flash Point | 209.6ºC |
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| Exact Mass | 307.097534 |
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| PSA | 72.72000 |
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| LogP | 3.36370 |
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| Vapour Pressure | 1.56E-11mmHg at 25°C |
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| InChIKey | SWWQQSDRUYSMAR-UHFFFAOYSA-N |
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| SMILES | Cl.Oc1ccc(CC2NCCc3cc(O)c(O)cc32)cc1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NX0484380
- CHEMICAL NAME :
- 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, hydrochloride, (+-)-
- CAS REGISTRY NUMBER :
- 11041-94-4
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C16-H17-N-O3.Cl-H
- MOLECULAR WEIGHT :
- 307.80
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 17250 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,489,1982
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Safety Information
Customs
| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-6(7H)-one |
| 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydrochloride (1:1) |
| 6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride |
| Higenamine HCl |
| UNII:PQ432PID6E |
| 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, hydrochloride (1:1) |
