Introduction：Basic information about CAS 951163-60-3|7-[(3S,5S)-3-amino-5-methylpiperidin-1-yl]-1-cyclopropyl-8-methoxy-4-oxoquinoline-3-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 7-[(3S,5S)-3-amino-5-methylpiperidin-1-yl]-1-cyclopropyl-8-methoxy-4-oxoquinoline-3-carboxylic acid,2-hydroxybutanedioic acid |
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| CAS Number | 951163-60-3 | Molecular Weight | 505.51800 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C24H31N3O9 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 7-[(3S,5S)-3-amino-5-methylpiperidin-1-yl]-1-cyclopropyl-8-methoxy-4-oxoquinoline-3-carboxylic acid,2-hydroxybutanedioic acid |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Nemonoxacin (TG-873870) malate is a nonfluorinated quinolone antibiotic. Nemonoxacin malate has broad-spectrum activity against Gram-positive, Gram-negative and atypical pathogens. Nemonoxacin malate can inhibit drug-resistant Streptococcus pneumoniae and (HY-121544) Methicillin-resistant Staphylococcus aureus. Nemonoxacin malate can be used for the research of community-acquired pneumonia[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Nemonoxacin has antibacterial activity against Chlamydia pneumoniae with MIC90s of 0.06 μg/mL[1]. Nemonoxacin has highly active against community-acquired MRSA (CA-MRSA) (MIC90: 0.5 and 0.06 μg/ml), and exerts limited activity against (HY-B0356) Ciprofloxacin-resistant MRSA (MIC90: 1 μg/ml), and (HY-B0671) Vancomycin-intermediate MRSA (MIC90: 2 μg/ml)[2]. |
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| References | [1]. Chotikanatis K, et al. In vitro activity of nemonoxacin, a novel nonfluorinated quinolone antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae. Antimicrob Agents Chemother. 2014;58(3):1800-1. [2]. Lai CC, et al. Nemonoxacin (TG-873870) for treatment of community-acquired pneumonia. Expert Rev Anti Infect Ther. 2014 Apr;12(4):401-17. |
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Chemical & Physical Properties
| Molecular Formula | C24H31N3O9 |
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| Molecular Weight | 505.51800 |
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| Exact Mass | 505.20600 |
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| PSA | 192.62000 |
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| LogP | 1.88860 |
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| InChIKey | YMVJINCWEIPOFL-FXMYHANSSA-N |
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| SMILES | COc1c(N2CC(C)CC(N)C2)ccc2c(=O)c(C(=O)O)cn(C3CC3)c12.O=C(O)CC(O)C(=O)O |
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Synonyms
| NEMONOXACIN MALIC ACID |
| 2-HYDROXY-BUTANEDIOIC ACID COMPD. WITH 7-[(3S,5S)-3-AMINO-5-METHYL-PIPERIDIN-1-YL]-1-CYCLOPROPYL-1,4-DIHYDRO-8-METHOXY-4-OXO-3-QUINOLINECARBOXYLIC ACID |
| 7-((3S,5S)-3-amino-5-methylpiperidin-1-yl)-1-cyclopropyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid malate |
