Introduction：Basic information about CAS 116064-77-8|Dehydromiltirone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dehydromiltirone |
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| CAS Number | 116064-77-8 | Molecular Weight | 280.36100 |
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| Density | 1.116g/cm3 | Boiling Point | 423.8ºC at 760mmHg |
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| Molecular Formula | C19H20O2 | Melting Point | / |
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| MSDS | / | Flash Point | 180.5ºC |
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Names
| Name | 8,8-dimethyl-2-propan-2-yl-7H-phenanthrene-3,4-dione |
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| Synonym | More Synonyms |
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Dehydromiltirone BiologicalActivity
| Description | Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research[1][2]. |
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| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Inflammation/Immunology |
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| In Vitro | Dehydromiltirone (100 μg/mL; 24 h) 抑制 Kupffer 细胞中的 p38 和 NF-κB 信号[1]。 Dehydromiltirone 抑制破骨细胞相关基因的表达，包括 NFATc1、CTSK、c-Fos、Acp5 和 MMP9；以及MAPK信号通路的 P38、ERK 和 JNK 的磷酸化；以及 NF-κB 信号通路中 IκB-α 的降解。Dehydromiltirone 通过降低相关基因的表达来发挥抗破骨细胞生成作用，最终在体外抑制骨吸收[2]。 Western Blot Analysis[1] Cell Line: Kupffer cells Concentration: 100 μg/mL Incubation Time: For 24 h Result: Significantly decreased p38 and p-p38 levels, NF-κBp65, IκB, and c-fos protein levels. |
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| In Vivo | Dehydromiltirone (50-200 mg/kg，口服；每天；连续五天) 保护肝脏免受 CCl4 诱导的损伤。Dehydromiltirone 可减少促炎细胞因子 TNF-α、IL-1 和 IL-6 的增加，表明它具有减轻肝脏炎症的作用[1]。 Animal Model: Rat model of acute liver injury[1] Dosage: 50 mg/kg, 100 mg/kg, and 200 mg/kg Administration: p.o.; daily; for five consecutive days Result: Protected liver from CCl4-induced damage. |
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| References | [1]. Shuqiang Yue, et al. Salvia miltiorrhiza compounds protect the liver from acute injury by regulation of p38 and NFκB signaling in Kupffer cells. Pharm Biol. 2014 Oct;52(10):1278-85. [2]. Wei Deng, et al. Dehydromiltirone inhibits osteoclast differentiation in RAW264.7 and bone marrow macrophages by modulating MAPK and NF-κB activity. Front Pharmacol. 2022 Sep 21;13:1015693. |
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Chemical & Physical Properties
| Density | 1.116g/cm3 |
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| Boiling Point | 423.8ºC at 760mmHg |
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| Molecular Formula | C19H20O2 |
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| Molecular Weight | 280.36100 |
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| Flash Point | 180.5ºC |
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| Exact Mass | 280.14600 |
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| PSA | 34.14000 |
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| LogP | 4.18590 |
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| Vapour Pressure | 2.17E-07mmHg at 25°C |
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| Index of Refraction | 1.57 |
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| InChIKey | FQRLDPKLRMEKLQ-UHFFFAOYSA-N |
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| SMILES | CC(C)C1=Cc2ccc3c(c2C(=O)C1=O)C=CCC3(C)C |
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Synonyms
| dehydromiltirone |
| 2-isopropyl-8,8-dimethyl-7.8-dihydrophenanthrene-3,4-dione |
| 1,2-didehydromiltirone |
