CAS 1228108-65-3|Sabutoclax

Introduction：Basic information about CAS 1228108-65-3|Sabutoclax, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Sabutoclax BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Sabutoclax
CAS Number	1228108-65-3	Molecular Weight	700.776
Density	1.4±0.1 g/cm3	Boiling Point	905.9±65.0 °C at 760 mmHg
Molecular Formula	C₄₂H₄₀N₂O₈	Melting Point	/
MSDS	/	Flash Point	501.7±34.3 °C

Names

Name	2,3,5-trihydroxy-7-methyl-N-[(2R)-2-phenylpropyl]-6-[1,6,7-trihydroxy-3-methyl-5-[[(2R)-2-phenylpropyl]carbamoyl]naphthalen-2-yl]naphthalene-1-carboxamide
Synonym	More Synonyms

Sabutoclax BiologicalActivity

Description	Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively.
Related Catalog	Signaling Pathways >>Apoptosis >>Bcl-2 FamilyResearch Areas >>Cancer
Target	Bcl-xL:0.31 μM (IC50) BCL2:0.32 μM (IC50) Mcl-1:0.2 μM (IC50) Bfl-1:0.62 μM (IC50)
References	[1]. Wei J , et al. BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem. 2010 May 27; 53(10):4166-76.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	905.9±65.0 °C at 760 mmHg
Molecular Formula	C₄₂H₄₀N₂O₈
Molecular Weight	700.776
Flash Point	501.7±34.3 °C
Exact Mass	700.278442
PSA	186.56000
LogP	7.47
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.713
InChIKey	RAYNZUHYMMLQQA-UXMRNZNESA-N
SMILES	Cc1cc2c(C(=O)NCC(C)c3ccccc3)c(O)c(O)cc2c(O)c1-c1c(C)cc2c(C(=O)NCC(C)c3ccccc3)c(O)c(O)cc2c1O
Storage condition	-20℃

Synonyms

1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5,N5'-bis(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide

[2,2'-Binaphthalene]-5,5'-dicarboxamide, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N,N-bis[(2R)-2-phenylpropyl]-

UNII:39Y89ZRK34

1,1',6,6',7,7'-HEXAHYDROXY-3,3'-DIMETHYL-N5-((R)-2-PHENYLPROPYL)-N5'-((R)-2-PHENYLPROPYL)-2,2'-BINAPHTHYL-5,5'-DICARBOXAMIDE (ATROPISOMERIC MIX)

Sabutoclax

UNII-39Y89ZRK34

1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N,N'-bis[(2R)-2-phenylpropyl]-2,2'-binaphthalene-5,5'-dicarboxamide

BI-97C1

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