CAS 21794-55-8|Daunomycinone
| Common Name | Daunomycinone | ||
|---|---|---|---|
| CAS Number | 21794-55-8 | Molecular Weight | 398.36 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 677.4±55.0 °C at 760 mmHg |
| Molecular Formula | C21H18O8 | Melting Point | 208-210°C |
| MSDS | / | Flash Point | 243.4±25.0 °C |
Names
| Name | Daunomycinone |
|---|---|
| Synonym | More Synonyms |
Daunomycinone BiologicalActivity
| Description | Daunomycinone (NSC-109351) is a metabolite of daunomycin. Daunomycin is an antibiotic with antitumor activity[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Cancer |
| References | [1]. Herman EH, et al. Modification of some of the toxic effects of daunomycin (NSC-82,151) by pretreatment with the antineoplastic agent ICRF 159 (NSC-129,943). Toxicol Appl Pharmacol. 1974 Mar;27(3):517-26. [2]. Tan C, et al. Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia. Cancer. 1967 Mar;20(3):333-53. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 677.4±55.0 °C at 760 mmHg |
| Melting Point | 208-210°C |
| Molecular Formula | C21H18O8 |
| Molecular Weight | 398.36 |
| Flash Point | 243.4±25.0 °C |
| Exact Mass | 398.100159 |
| PSA | 141.36000 |
| LogP | 2.93 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.713 |
| InChIKey | YOFDHOWPGULAQF-MQJDWESPSA-N |
| SMILES | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)CC(O)(C(C)=O)CC3O |
| Storage condition | -20°C Freezer |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 2 umol/L
- REFERENCE :
- CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year: 68,115,1978
- TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 2 umol/L
- REFERENCE :
- CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year: 68,115,1978
Safety Information
| RIDADR | UN 2811 6.1 / PGIII |
|---|
Articles23
More Articles| Semiquinone free radical formation by daunorubicin aglycone incorporated into the cellular membranes of intact Chinese hamster ovary cells. Free Radic. Res. 24(1) , 9-18, (1996) The production of semiquinone free radicals has been measured by electron paramagnetic resonance spectroscopy (EPR) in Chinese hamster ovary cells in which 7-hydroxy daunorubicin aglycone had been inc... | |
| Biotransformation of aklanonic acid by blocked mutants of anthracycline-producing strains of Streptomyces galilaeus and Streptomyces peucetius. J. Basic Microbiol. 26(4) , 249-55, (1986) Aklanonic acid is an anthracyclinone-related pigment that was found to be an intermediate at an early stage of the biosynthesis of daunomycinone glycosides by Streptomyces griseus. We now isolated ant... | |
| Synthesis and biological activity of (7S)-O-epoxyalkyl derivatives of daunomycinone. J. Antibiot. 38(12) , 1714-8, (1985) Synthesis and antibacterial activity of a number of 7-O-epoxyalkyl derivatives of daunomycinone prepared from 7-O-alkenyl derivatives of daunomycinone are described along with their inhibitory effect ... |
Synonyms
| 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-, (8S,10S)- |
| (8S,10S)-8-Acetyl-6,8,10,11-tetrahydroxy-1-methoxy-7,8,9,10-tetrahydro-5,12-tetracenedione |
| daunomycinone |
| 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-, (8S-cis)- |
| (8S,10S)-8-Acetyl-6,8,10,11-tetrahydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione |
