Introduction：Basic information about CAS 85532-77-0|Safflor yellow A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Safflor yellow A |
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| CAS Number | 85532-77-0 | Molecular Weight | 610.51700 |
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| Density | 1.81g/cm3 | Boiling Point | 942.3ºC at 760 mmHg |
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| Molecular Formula | C27H30O15 | Melting Point | / |
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| MSDS | / | Flash Point | 313ºC |
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Names
Safflor yellow A BiologicalActivity
| Description | Safflor yellow A, a flavonoid extracted from Carthamus tinctorius L, is a water-soluble monomer of safflor yellow. Safflor yellow A protects rat cardiomyocytes against anoxia/reoxygenation (A/R) injury via inhibiting cellular oxidative stress and apoptosis[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cardiovascular DiseaseResearch Areas >>Inflammation/Immunology |
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| In Vivo | Pretreatment with Safflor yellow A (40, 60 and 80 nM) concentration-dependently blockes the A/R-induced changes in the cardiomyocytes in 1- to 3-d-old Sprague-Dawley rats [1]. |
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| References | [1]. Duan JL, et al. Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro. Acta Pharmacol Sin. 2013 Apr;34(4):487-95. |
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Chemical & Physical Properties
| Density | 1.81g/cm3 |
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| Boiling Point | 942.3ºC at 760 mmHg |
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| Molecular Formula | C27H30O15 |
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| Molecular Weight | 610.51700 |
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| Flash Point | 313ºC |
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| Exact Mass | 610.15300 |
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| PSA | 273.36000 |
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| Index of Refraction | 1.764 |
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| InChIKey | CHYLAEHATFZYSW-YFGZFMDZSA-N |
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| SMILES | O=C(C=Cc1ccc(O)cc1)C1=C(O)C2=C(OC3C2OC(CO)C(O)C3O)C(O)(C2OC(CO)C(O)C(O)C2O)C1=O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UQ0333750
- CHEMICAL NAME :
- 9H-Pyrano(3,2-b)benzofuran-9-one, 2,3,4,4a,6,9b-hexahydro-6-beta-D-glucopyranosyl-2- (hydroxymethyl)-8-(3-(4-hydroxyphenyl)-1-oxo-2-propen yl)-3,4,6,7-tetrahydr oxy-
- CAS REGISTRY NUMBER :
- 85532-77-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C27-H30-O15
- MOLECULAR WEIGHT :
- 594.57
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5530 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,348,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5490 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,348,1984
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