Introduction：Basic information about CAS 153-87-7|oxypertine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | oxypertine |
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| CAS Number | 153-87-7 | Molecular Weight | 379.49500 |
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| Density | 1.157g/cm3 | Boiling Point | 555.5ºC at 760 mmHg |
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| Molecular Formula | C23H29N3O2 | Melting Point | / |
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| MSDS | / | Flash Point | 289.8ºC |
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Names
| Name | oxypertine |
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| Synonym | More Synonyms |
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oxypertine BiologicalActivity
| Description | Oxypertine is a neuroprotective agent. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vitro | Oxypertine (0.44 nM-26 μM, 15 min) antagonizes dopamine and 5-HT induced contractions of the rat isolated vas deferens[1]. Oxypertine (8.8 nM, 15 min) reduces the contractions evoked by transmural stimulation of the vas deferens[1]. |
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| In Vivo | Oxypertine (10 and 35 mg/kg, i.p.) causes an obvious dose-related depletion in the levels of norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) in various discrete regions of the rat brain[2]. Oxypertine (0.625-20 mg/kg, i.p.) inhibits stereotyped behaviour induced by both amphetamine and apomorphine in rats[3]. Animal Model: Mice with chronic restraint stress[2] Dosage: 10, 35 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Increased the level of homovanillic acid in three discrete regions, i.e., the cortex, striatum and mid-brain. Inhibited Apomorphine-induced stereotypy. Animal Model: Mice with stereotyped behaviour induced by amphetamine (5.0 mg/kg i.p.) and apomorphine (1.0 mg/kg, s.c.)[3] Dosage: 0.625-20 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Reduced the content of dopamine in the striatum but increased the concentrations of homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC). |
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Chemical & Physical Properties
| Density | 1.157g/cm3 |
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| Boiling Point | 555.5ºC at 760 mmHg |
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| Molecular Formula | C23H29N3O2 |
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| Molecular Weight | 379.49500 |
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| Flash Point | 289.8ºC |
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| Exact Mass | 379.22600 |
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| PSA | 40.73000 |
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| LogP | 3.86110 |
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| Vapour Pressure | 2.22E-12mmHg at 25°C |
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| Index of Refraction | 1.614 |
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| InChIKey | XCWPUUGSGHNIDZ-UHFFFAOYSA-N |
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| SMILES | COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NL7170000
- CHEMICAL NAME :
- Indole, 5,6-dimethoxy-2-methyl-3-(2-(4-phenyl-1-piperazinyl)e thyl)-
- CAS REGISTRY NUMBER :
- 153-87-7
- BEILSTEIN REFERENCE NO. :
- 0899339
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C23-H29-N3-O2
- MOLECULAR WEIGHT :
- 379.55
- WISWESSER LINE NOTATION :
- T56 BMJ C1 GO1 HO1 D2- AT6N DNTJ DR
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 154 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 26,186,1966
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Safety Information
| RIDADR | UN 3249 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Integrin |
| EINECS 205-818-3 |
| Opertil |
| Equipertine |
| Forit |
