Introduction：Basic information about CAS 128-46-1|Dihydrostreptomycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dihydrostreptomycin |
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| CAS Number | 128-46-1 | Molecular Weight | 583.590 |
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| Density | 2.0±0.1 g/cm3 | Boiling Point | 879.5±75.0 °C at 760 mmHg |
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| Molecular Formula | C21H41N7O12 | Melting Point | 210 - 212ºC |
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| MSDS | / | Flash Point | 485.7±37.1 °C |
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Names
| Name | dihydrostreptomycin |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Density | 2.0±0.1 g/cm3 |
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| Boiling Point | 879.5±75.0 °C at 760 mmHg |
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| Melting Point | 210 - 212ºC |
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| Molecular Formula | C21H41N7O12 |
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| Molecular Weight | 583.590 |
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| Flash Point | 485.7±37.1 °C |
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| Exact Mass | 583.281311 |
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| PSA | 334.59000 |
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| LogP | -3.38 |
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| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
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| Index of Refraction | 1.762 |
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| InChIKey | ASXBYYWOLISCLQ-HZYVHMACSA-N |
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| SMILES | CNC1C(OC2C(OC3C(O)C(O)C(N=C(N)N)C(O)C3N=C(N)N)OC(C)C2(O)CO)OC(CO)C(O)C1O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- WK2450000
- CHEMICAL NAME :
- Streptamine, O-beta-D-mannopyranosyl-(1-4)-2-deoxy-2-(methylamino) -alpha-L-glucopyranos yl- (1-2)-5-deoxy-O-3-C-(hydroxymethyl)-alpha-L-lyxofuran osyl-(1-4)-N,N'-diami dino-, D-
- CAS REGISTRY NUMBER :
- 128-46-1
- LAST UPDATED :
- 199603
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C21-H41-N7-O12
- MOLECULAR WEIGHT :
- 583.69
- WISWESSER LINE NOTATION :
- T6OTJ CM1 DQ EQ F1Q BO- CT5OTJ DQ D1Q E1 BO- AL6TJ BQ CQ DMYZUM EQ FMYZUM
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 533 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 260 mg/kg
- SEX/DURATION :
- female 19-22 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 400 mg/kg
- SEX/DURATION :
- female 1-16 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 600 mg/kg
- SEX/DURATION :
- female 6-10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 7500 mg/kg
- SEX/DURATION :
- female 5-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 12 gm/kg
- SEX/DURATION :
- female 1-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- REFERENCE :
- NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958- Volume(issue)/page/year: 14,161,1971
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Synonyms
| Dihydrostreptomycin |
| Abiocine |
| Dihydrostreptomycine |
| Panstreptin |
| DST |
| dhms |
| O-2-Deoxy-2-(methylamino)-a-L-glucopyranosyl-(1®2)-O-5-deoxy-3C-(hydroxymethyl)-a-L-lyxofuranosyl-(1®4)-N,N'-bis(aminoiminomethyl)-D-streptamine |
| Acetonitrile,2-benzimidazolyl |
| dihydro-streptomyci |
| 1,1'-[(1R,2R,3S,4R,5R,6S)-4-({5-Deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl)-α-L-lyxofuranosyl}oxy)-2,5,6-trihydroxy-1,3-cyclohexanediyl]diguanidine |
| Guanidine, N,N'''-[(1R,2R,3S,4R,5R,6S)-4-[[5-deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl)-α-L-lyxofuranosyl]oxy]-2,5,6-trihydroxy-1,3-cyclohexanediyl]bis- |
| Vibriomycin |
| 1,1'-[(1R,2R,3S,4R,5R,6S)-4-({5-Deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl)-α-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine |
| MFCD00084778 |
| Benzimidazole,2-cyanomethyl |
| UNII-P2I6R8W6UA |
| EINECS 204-888-2 |
| DHSM |
