Introduction：Basic information about CAS 1404-64-4|Sparsomycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sparsomycin |
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| CAS Number | 1404-64-4 | Molecular Weight | 361.44 |
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| Density | 1.466g/cm3 | Boiling Point | / |
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| Molecular Formula | C13H19N3O5S2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | sparsomycin |
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| Synonym | More Synonyms |
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Sparsomycin BiologicalActivity
| Description | Sparsomycin is a metabolite of the bacterium Streptomyces sparsogenes. Sparsomycin inhibits protein synthesis in both eukaryotic cells and bacteria. Sparsomycin inhibits the translation extension of ribosome PTC[1]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| References | [1]. Codjo H, et, al. COVID-19: Mechanisms of the Antiviral Activities of Selective Antibiotics Targeting the Human 80S Ribosome. 2021;15:38-52. [2]. Lazaro E, et, al. Interaction of the antibiotic sparsomycin with the ribosome. Antimicrob Agents Chemother. 1991 Jan;35(1):10-3. |
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Chemical & Physical Properties
| Density | 1.466g/cm3 |
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| Molecular Formula | C13H19N3O5S2 |
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| Molecular Weight | 361.44 |
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| Exact Mass | 361.07700 |
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| PSA | 176.63000 |
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| LogP | 0.18770 |
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| Index of Refraction | 1.656 |
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| InChIKey | XKLZIVIOZDNKEQ-CLQLPEFOSA-N |
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| SMILES | CSCS(=O)CC(CO)NC(=O)C=Cc1c(C)[nH]c(=O)[nH]c1=O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- WG5850000
- CHEMICAL NAME :
- Sparsomycin
- CAS REGISTRY NUMBER :
- 1404-64-4
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C13-H19-N3-O5-S2
- MOLECULAR WEIGHT :
- 361.47
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 22 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 20 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973
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Safety Information
| Hazard Codes | T+: Very toxic; |
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| Risk Phrases | 28 |
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| Safety Phrases | 28-36/37-45 |
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| RIDADR | UN 2811 6.1/PG 2 |
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Synonyms
| Sparsomycin from Streptomyces sparsogenes |
| sparsamycin |
