Introduction：Basic information about CAS 1402-82-0|Amphomycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Amphomycin |
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| CAS Number | 1402-82-0 | Molecular Weight | 1290.42000 |
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| Density | 1.37g/cm3 | Boiling Point | 1693.3ºC at 760 mmHg |
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| Molecular Formula | C58H91N13O20 | Melting Point | / |
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| MSDS | / | Flash Point | 977.9ºC |
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Names
Amphomycin BiologicalActivity
| Description | Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci[1][2][3]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Amphomycin (40 μ g/mL; 60 min) leads S. aureus to exhibit cell wall thinning and Park’s nucleotide accumulation[1]. Cell Viability Assay[1] Cell Line: S. aureus whole cells Concentration: 40 μ g/mL Incubation Time: 60 min Result: Resulted in the thinning of cell wall and the accumulation of Park’s nucleotide. |
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| In Vivo | Amphomycin (50 mg/kg; p.o.; single) shows low oral availability and (5-10mg/kg; i.v.; single) exhibits a long half-life (5.2-8.0 h in mice and 4.6-7.1 h in rats)[2]. |
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Chemical & Physical Properties
| Density | 1.37g/cm3 |
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| Boiling Point | 1693.3ºC at 760 mmHg |
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| Molecular Formula | C58H91N13O20 |
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| Molecular Weight | 1290.42000 |
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| Flash Point | 977.9ºC |
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| Exact Mass | 1289.65000 |
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| PSA | 506.84000 |
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| LogP | 0.52660 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.599 |
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| InChIKey | WAFOSUDOWLQGBG-YZAYYAESSA-N |
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| SMILES | CCC(C)CCCCCC=CCC(=O)NC(CC(=O)O)C(=O)NC1C(=O)N2CCCCC2C(=O)NC(C(C)C(=O)O)C(=O)NC(CC(=O)O)C(=O)NCC(=O)NC(CC(=O)O)C(=O)NCC(=O)NC(C(C)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC1C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- BU2100000
- CHEMICAL NAME :
- Amphomycin
- CAS REGISTRY NUMBER :
- 1402-82-0
- LAST UPDATED :
- 199109
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),317,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 233 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 30,9,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 178 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,131,1967
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