CAS 5417-82-3|2-(1-Ethoxyethylidene)malononitrile

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TY1510000

CHEMICAL NAME :

Propanedinitrile, (1-ethoxyethylidene)-

CAS REGISTRY NUMBER :

5417-82-3

BEILSTEIN REFERENCE NO. :

0906913

LAST UPDATED :

199710

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C7-H8-N2-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

312 mg/kg

TOXIC EFFECTS :

Gastrointestinal - ulceration or bleeding from stomach Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring) Blood - changes in spleen

REFERENCE :

EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0487-0663 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6425 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

J. Comb. Chem. 12(1) , 69-74, (2010)

A solid-phase synthesis of 5-aminopyrazole has been developed and applied to the preparation of pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones. In this strategy, a one-pot reaction from 5-aminopyrazoles...

Eur. J. Med. Chem. 46(12) , 5825-32, (2011)

The design and synthesis of a small library of 4-aminopyrido[2,3-d]pyrimidine derivatives is reported. The potential activity of these compounds as CDK2/Cyclin A, CDK4/Cyclin D, EGFR and anti-tumor wa...