CAS 865536-65-8|4-oxo-4-HPR

Introduction：Basic information about CAS 865536-65-8|4-oxo-4-HPR, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 4-oxo-4-HPR BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	4-oxo-4-HPR
CAS Number	865536-65-8	Molecular Weight	405.53
Density	1.131g/cm3	Boiling Point	641.8ºC at 760 mmHg
Molecular Formula	C₂₆H₃₁NO₃	Melting Point	/
MSDS	/	Flash Point	341.9ºC

Names

Name	(2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxocyclohexen-1-yl)nona-2,4,6,8-tetraenamide
Synonym	More Synonyms

4-oxo-4-HPR BiologicalActivity

Description	4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9[1].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Others >>Others
References	[1]. VillaniMG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite,induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitiveand fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47. [2]. Villani MG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.

Description

4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9[1].

Related Catalog

Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Others >>Others

References

[1]. VillaniMG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite,induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitiveand fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.

[2]. Villani MG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.

Chemical & Physical Properties

Density	1.131g/cm3
Boiling Point	641.8ºC at 760 mmHg
Molecular Formula	C₂₆H₃₁NO₃
Molecular Weight	405.53
Flash Point	341.9ºC
Exact Mass	405.23000
PSA	66.40000
LogP	6.11430
Index of Refraction	1.615
InChIKey	NZVOGZATHCUFRC-KFJFTADJSA-N
SMILES	CC(C=CC1=C(C)C(=O)CCC1(C)C)=CC=CC(C)=CC(=O)Nc1ccc(O)cc1
Storage condition	-20℃

Synonyms

4-oxo-4-HPR

N-(4-Hydroxyphenyl)-4-oxoretinamide

4-oxo-N-(4-hydroxyphenyl)retinamide

3-Keto fenretinide

4-Oxo Fenretinide

4-Keto-4-HPR

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