Introduction：Basic information about CAS 40951-69-7|Taxiresinol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Taxiresinol |
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| CAS Number | 40951-69-7 | Molecular Weight | 346.37 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 590.3±50.0 °C at 760 mmHg |
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| Molecular Formula | C19H22O6 | Melting Point | / |
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| MSDS | / | Flash Point | 310.8±30.1 °C |
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Names
| Name | 4-[4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)oxolan-2-yl]benzene-1,2-diol |
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| Synonym | More Synonyms |
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Taxiresinol BiologicalActivity
| Description | Taxiresinol is an orally active and potent lignan, that can be isolated from the heartwood of Taxus baccata. Taxiresinol shows significant antinociceptive activity[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
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| In Vivo | Taxiresinol (100 mg/kg，口服，一次) 对对苯醌(p-benzoquinone)诱导的小鼠腹部收缩表现出显著的镇痛作用[1]。 Animal Model: Male Swiss albino mice (20-25 g)[1] Dosage: 100 mg/kg Administration: Oral administration, sixty minutes after the oral administration of test sample, the mice were intraperitoneally injected with 0.1 ml/10 g body weight of 2.5% (v/v) p-benzoquinone solution in distilled H2O. Result: Showed significant antinociceptive activity against p-benzoquinone-induced abdominal contractions (writhing movements) in mice, with a inhibitory ratio of 37.8%. |
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| References | [1]. Küpeli E, et al. Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L. J Ethnopharmacol. 2003 Dec;89(2-3):265-70. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 590.3±50.0 °C at 760 mmHg |
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| Molecular Formula | C19H22O6 |
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| Molecular Weight | 346.37 |
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| Flash Point | 310.8±30.1 °C |
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| Exact Mass | 346.141632 |
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| PSA | 99.38000 |
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| LogP | 1.33 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.627 |
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| InChIKey | SNZZAHRDXCGWEM-LPMFXHHGSA-N |
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| SMILES | COc1cc(CC2COC(c3ccc(O)c(O)c3)C2CO)ccc1O |
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Safety Information
Synonyms
| 1,2-Benzenediol, 4-[(2S,3R,4R)-tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)-2-furanyl]- |
| 4-[(2S,3R,4R)-4-(4-Hydroxy-3-methoxybenzyl)-3-(hydroxymethyl)tetrahydro-2-furanyl]-1,2-benzenediol |
