Introduction：Basic information about CAS 80454-42-8|Paeoniflorigenone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Paeoniflorigenone |
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| CAS Number | 80454-42-8 | Molecular Weight | 318.321 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 481.1±45.0 °C at 760 mmHg |
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| Molecular Formula | C17H18O6 | Melting Point | / |
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| MSDS | / | Flash Point | 177.1±22.2 °C |
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Names
| Name | Paeoniflorigenone |
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| Synonym | More Synonyms |
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Paeoniflorigenone BiologicalActivity
| Description | Paeoniflorigenone, isolated as an active ingredient from the root of moutan cortex, induces apoptosis selectively in the cancer cell lines and exhibits antiproliferative effect[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| In Vitro | Paeoniflorigenone (0-30 μM; 0-72 hours) significantly decreases the cell proliferation of tumor cell lines and inhibits the proliferation of normal cell lines[1]. Paeoniflorigenone (0-30 μM; 24-72 hours) significantly induces apoptotic DNA fragmentation selectively in tumor cells[1]. Cell Proliferation Assay[1] Cell Line: TIG-1, 3T3-L1, HL60, Jurkat and HeLa cells Concentration: 0-30 μM Incubation Time: 0-72 hours Result: Significantly decreased the cell proliferation of tumor cell lines and inhibited the proliferation of normal cell lines. Apoptosis Analysis[1] Cell Line: TIG-1 and 3T3-L1 (normal cells), HL60, Jurkat, and HeLa cells (tumor cells) Concentration: 0, 1, 3, 10, 30 μM Incubation Time: 24 and 72 hours Result: Induced DNA fragmentation in three tumor cell lines, but not in two normal cell lines. |
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| References | [1]. Huang Y, et al. Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex. Biosci Biotechnol Biochem. 2017;81(6):1106-1113. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 481.1±45.0 °C at 760 mmHg |
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| Molecular Formula | C17H18O6 |
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| Molecular Weight | 318.321 |
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| Flash Point | 177.1±22.2 °C |
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| Exact Mass | 318.110352 |
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| PSA | 82.06000 |
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| LogP | 2.87 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.605 |
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| InChIKey | BANPEMKDTXIFRE-UHFFFAOYSA-N |
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| SMILES | CC12CC(=O)C3CC1(O)OC(O2)C3COC(=O)c1ccccc1 |
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Safety Information
Synonyms
| [(1S,3R,6S,8S,10S)-8-Hydroxy-3-methyl-5-oxo-2,9-dioxatricyclo[4.3.1.0]dec-10-yl]methyl benzoate |
| 2,5-Methano-1,3-benzodioxol-6(5H)-one, 8-[(benzoyloxy)methyl]tetrahydro-3a-hydroxy-7a-methyl-, (2S,3aS,5S,7aR,8S)- |
