CAS 304464-97-9|8-Demethyl Ivabradine

Introduction：Basic information about CAS 304464-97-9|8-Demethyl Ivabradine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 8-Demethyl Ivabradine BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	8-Demethyl Ivabradine
CAS Number	304464-97-9	Molecular Weight	454.559
Density	1.2±0.1 g/cm3	Boiling Point	643.9±55.0 °C at 760 mmHg
Molecular Formula	C₂₆H₃₄N₂O₅	Melting Point	/
MSDS	/	Flash Point	343.2±31.5 °C

Names

Name	3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7-hydroxy-8-methoxy-2,5-dihydro-1H-3-benzazepin-4-one
Synonym	More Synonyms

8-Demethyl Ivabradine BiologicalActivity

Description	8-Demethyl Ivabradine is a metabolite of Ivabradine. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker[1].
Related Catalog	Research Areas >>Endocrinology
References	[1]. M François-Bouchard,et al. Simultaneous determination of ivabradine and its metabolites in human plasma by liquid chromatography--tandem mass spectrometry. J Chromatogr B Biomed Sci Appl. 2000 Aug 18;745(2):261-9.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	643.9±55.0 °C at 760 mmHg
Molecular Formula	C₂₆H₃₄N₂O₅
Molecular Weight	454.559
Flash Point	343.2±31.5 °C
Exact Mass	454.246765
PSA	71.47000
LogP	2.92
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.580

Synonyms

8-Demethyl Ivabradine

2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-8-hydroxy-7-methoxy-

3-{3-[{[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-8-hydroxy-7-methoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-8-hydroxy-7-methoxy-2H-3-benzazepin-2-one

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