Introduction：Basic information about CAS 122795-43-1|Gadodiamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Gadodiamide |
|---|
| CAS Number | 122795-43-1 | Molecular Weight | 591.67200 |
|---|
| Density | / | Boiling Point | 769.1ºC at 760mmHg |
|---|
| Molecular Formula | C16H28GdN5O9 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 419ºC |
|---|
Names
| Name | gadodiamide hydrate |
|---|
| Synonym | More Synonyms |
|---|
Gadodiamide BiologicalActivity
| Description | Gadodiamide is a gadolinium-based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. Target: OthersGadodiamide(Omniscan) is a gadolinium-based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. Gadodiamide is a contrast medium for cranial and spinal magnetic resonance imaging (MRI) and for general MRI of the body after intravenous administration. The product provides contrast enhancement and facilitates visualisation of abnormal structures or lesions in various parts of the body including the central nervous system (CNS). A recent review takes the question of toxicity caused by loss of gadolinium from the complex. "The challenge for nephrologists includes (a) evidence of transmetallation, such as gadolinium deposits in bone, increased urinary zinc excretion, iron-transferrin dissociation or 'spurious hypocalcemia' in exposed people" [1]. |
|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Others |
|---|
| References | [1]. Canavese, C., et al., Gadolinium-associated nephrogenic systemic fibrosis: the need for nephrologists' awareness. J Nephrol, 2008. 21(3): p. 324-36. |
|---|
Chemical & Physical Properties
| Boiling Point | 769.1ºC at 760mmHg |
|---|
| Molecular Formula | C16H28GdN5O9 |
|---|
| Molecular Weight | 591.67200 |
|---|
| Flash Point | 419ºC |
|---|
| Exact Mass | 592.11300 |
|---|
| PSA | 156.05000 |
|---|
| InChIKey | XPCLDSMKWNNKOM-UHFFFAOYSA-K |
|---|
| SMILES | CNC(=O)CN(CCN(CCN(CC(=O)[O-])CC(=O)NC)CC(=O)[O-])CC(=O)[O-].O.[Gd+3] |
|---|
| Storage condition | -20℃ |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- LW3937500
- CHEMICAL NAME :
- Gadolinium, aqua(5,8-bis(carboxymethyl)-11-(2-(methylamino)-2-oxo ethyl)- 3-oxo-2,5,8,11-tetraazatridecan-13-oato(3-))-, hydrate
- CAS REGISTRY NUMBER :
- 122795-43-1
- LAST UPDATED :
- 199607
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C16-H28-Gd-N5-O9.xH2-O
- MOLECULAR WEIGHT :
- 717.88
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 16269 mg/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - biochemical and metabolic
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 14,78,1994
|
Synonyms
| Gadodiamide hydrate |
| Omniscan |
| 2-[bis[2-[carboxylatomethyl-[2-(methylamino)-2-oxoethyl]amino]ethyl]amino]acetate,gadolinium(3+),hydrate |
