CAS 43121-43-3|Triadimefon

Introduction：Basic information about CAS 43121-43-3|Triadimefon, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Triadimefon BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles32
8. Synonyms

Common Name	Triadimefon
CAS Number	43121-43-3	Molecular Weight	293.749
Density	1.2±0.1 g/cm3	Boiling Point	441.9±55.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₆ClN₃O₂	Melting Point	82°C
MSDS	ChineseUSA	Flash Point	221.0±31.5 °C
Symbol	GHS07, GHS09	Signal Word	Warning

Names

Name	triadimefon
Synonym	More Synonyms

Triadimefon BiologicalActivity

Description	Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees. Triadimefon inhibits lanosterol 14α-demethylase, interfering with oxidative demethylation reactions in the ergosterol biosynthesis pathway of fungi, and also blocks gibberellin biosynthesis.
Related Catalog	Signaling Pathways >>Anti-infection >>Fungal

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	441.9±55.0 °C at 760 mmHg
Melting Point	82°C
Molecular Formula	C₁₄H₁₆ClN₃O₂
Molecular Weight	293.749
Flash Point	221.0±31.5 °C
Exact Mass	293.093109
PSA	57.01000
LogP	2.77
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.580
InChIKey	WURBVZBTWMNKQT-UHFFFAOYSA-N
SMILES	CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n1cncn1
Water Solubility	0.026 G/100 ML

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EL7100000

CHEMICAL NAME :: 2-Butanone, 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-y l)-

CAS REGISTRY NUMBER :: 43121-43-3

BEILSTEIN REFERENCE NO. :: 0619231

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C14-H16-Cl-N3-O2

MOLECULAR WEIGHT :: 293.78

WISWESSER LINE NOTATION :: T5NN DNJ AYOR DG&VX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 363 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2450 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2337 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5800 ug/m3/17W-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Blood - methemoglobinemia-carboxyhemoglobin Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5800 ug/m3/17W-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Blood - methemoglobinemia-carboxyhemoglobin Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,157,1995 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

Safety Information

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H317-H410
Precautionary Statements	P280-P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn,N,T,F
Risk Phrases	R22
Safety Phrases	24-37-61-45-36/37
RIDADR	2588
WGK Germany	3
RTECS	EL7100000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933990014

Customs

HS Code	2933990014
Summary	2933990014 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1h-1,2,4-triazol-1-yl)butan-2-one。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

Articles32

Is the amphibian X. laevis WEC a good alternative method to rodent WEC teratogenicity assay? The example of the three triazole derivative fungicides Triadimefon, Tebuconazole, Cyproconazole.

Reprod. Toxicol. 32(2) , 220-6, (2011)

The aim of the present work is the assessment of teratogenic effects of three triazole-derived fungicides (Triadimefon, FON, Tebuconazole, TEBU, Cyproconazole, CYPRO) on rat and Xenopus laevis embryos...

Stage-dependent abnormalities induced by the fungicide triadimefon in the mouse.

Reprod. Toxicol. 31(2) , 194-9, (2011)

Aim of this work is the study of abnormalities induced by the triazole triadimefon (FON) administered to pregnant mice at E8, E9, E10, E11 or E12. Pregnant CD-1 mouse were gavaged with FON 500 mg/kg a...

Changes of thyroid hormone levels and related gene expression in zebrafish on early life stage exposure to triadimefon.

Environ. Toxicol. Pharmacol. 32(3) , 472-7, (2011)

In this study, zebrafish was exposed to triadimefon. Thyroid hormones levels and the expression of related genes in the hypothalamic-pituitary-thyroid (HPT) axis, including thyroid-stimulating hormone...

Synonyms

2-Butanone, 1- (4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-

Triadimefone

UNII:1HW039CJF0

Triadimeform

MILTEK

MFCD00055506

1-(4-Chlorphenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-on

2-Butanone, 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-

ACIZOL

BAY 6681F

1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one

BAY 6681 F

BAY-MEB-6447

Bay MEB 6447

Fenxiunin

SAMETON

ROFON

Azocene

1-(4-Chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone

OTRIA

EINECS 256-103-8

(RS)-1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

NUREX

DAYTON

Triadimefon

Amiral

TYPHON

rac-(1R)-1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

Recommended......