CAS 7365-45-9|HEPES
| Common Name | HEPES | ||
|---|---|---|---|
| CAS Number | 7365-45-9 | Molecular Weight | 238.305 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C8H18N2O4S | Melting Point | 234-238 °C |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid |
|---|---|
| Synonym | More Synonyms |
HEPES BiologicalActivity
| Description | HEPES, a zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is a potent inducer of lysosome biogenesis[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492. [3]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 2018;14(3):437-449. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Melting Point | 234-238 °C |
| Molecular Formula | C8H18N2O4S |
| Molecular Weight | 238.305 |
| Exact Mass | 238.098724 |
| PSA | 89.46000 |
| LogP | -2.67 |
| Index of Refraction | 1.543 |
| InChIKey | JKMHFZQWWAIEOD-UHFFFAOYSA-N |
| SMILES | O=S(=O)(O)CCN1CCN(CCO)CC1 |
| Storage condition | 2-8°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. Protect from moisture. |
| Water Solubility | Soluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- >316 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9468 No. of Facilities: 239 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3025 (estimated) No. of Female Employees: 2233 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S24/25-S22-S36-S26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| RTECS | TL6809000 |
| HS Code | 29335995 |
Customs
| HS Code | 29335995 |
|---|
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Synonyms
| 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid |
| hepesfreeacid |
| 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid |
| HEPES.1/2Na |
| 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid |
| EIT hydrobromide |
| hepes solution |
| 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)- |
| 4-(2-hydroxyethyl)-1-piperazineethanesulphonic acid |
| GOOD'S BUFFER |
| HEPES |
| HEPES BUFFER PH 8.0 |
| 2-[4-(2-Hydroxyethyl)-1-piperazinyl]ethanesulfonic acid |
| EINECS 230-907-9 |
| HEPES,1M solution |
| MFCD00006158 |
