CAS 128-53-0|N-ethylmaleimide

Introduction：Basic information about CAS 128-53-0|N-ethylmaleimide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. N-ethylmaleimide BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles253
8. Synonyms

Common Name	N-ethylmaleimide
CAS Number	128-53-0	Molecular Weight	125.13
Density	1.2±0.1 g/cm3	Boiling Point	210.0±9.0 °C at 760 mmHg
Molecular Formula	C₆H₇NO₂	Melting Point	43-46 °C(lit.)
MSDS	ChineseUSA	Flash Point	73.3±0.0 °C
Symbol	GHS05, GHS06	Signal Word	Danger

Names

Name	N-ethylmaleimide
Synonym	More Synonyms

N-ethylmaleimide BiologicalActivity

Description	N-Ethylmaleimide (NEM) is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Metabolic Enzyme/Protease >>Cathepsin
Target	Cysteine protease[1]
References	[1]. Wu KH, et al. Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolyticactivity of CvaB, an ATP-binding cassette transporter. J Biol Chem. 2004 Jan 9;279(2):901-9. [2]. Hatase O , et al. Specific inhibition of phosphate transport in mitochondria by N-ethylmaleimide. Journal of Bioenergetics, 1973, 5(1):1-15.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	210.0±9.0 °C at 760 mmHg
Melting Point	43-46 °C(lit.)
Molecular Formula	C₆H₇NO₂
Molecular Weight	125.13
Flash Point	73.3±0.0 °C
Exact Mass	125.047676
PSA	37.38000
LogP	0.68
Vapour Pressure	0.2±0.4 mmHg at 25°C
Index of Refraction	1.514
InChIKey	HDFGOPSGAURCEO-UHFFFAOYSA-N
SMILES	CCN1C(=O)C=CC1=O
Storage condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate.
Water Solubility	1 g/L (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9625000

CHEMICAL NAME :: 1H-Pyrrole-2,5-dione, 1-ethyl-

CAS REGISTRY NUMBER :: 128-53-0

BEILSTEIN REFERENCE NO. :: 0112448

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C6-H7-N-O2

MOLECULAR WEIGHT :: 125.14

WISWESSER LINE NOTATION :: T5VNVJ B2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1669 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 750 nmol/L

REFERENCE :: 32YWA5 "Radiation Research, Biomedical, Chemical, and Physical Perspectives, Proceedings of the International Congress of Radiation Research, 5th, Seattle, 1974," Nygaard, O.F., et al., eds., New York, Academic Press, Inc., 1975 Volume(issue)/page/year: -,742,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4314 No. of Facilities: 132 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 2547 (estimated) No. of Female Employees: 1922 (estimated)

Safety Information

Symbol	GHS05, GHS06
Signal Word	Danger
Hazard Statements	H300-H311-H314-H317
Precautionary Statements	P264-P280-P301 + P310-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+:Verytoxic;
Risk Phrases	R20/21;R28;R34;R43
Safety Phrases	S26-S28-S36/37/39-S45-S28A
RIDADR	UN 2928 6.1/PG 2
WGK Germany	3
RTECS	UX9625000
Packaging Group	II
Hazard Class	6.1
HS Code	2925190090

Customs

HS Code	2925190090
Summary	2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles253

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Biochem. Biophys. Res. Commun. 456(1) , 298-304, (2014)

RIPK3 is a key molecule for necroptosis, initially characterized by necrotic cell death morphology and the activation of autophagy. Cell death and autophagic signaling are believed to tightly regulate...

Extensive diversity of prion strains is defined by differential chaperone interactions and distinct amyloidogenic regions.

PLoS Genet. 10(5) , e1004337, (2014)

Amyloidogenic proteins associated with a variety of unrelated diseases are typically capable of forming several distinct self-templating conformers. In prion diseases, these different structures, call...

Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease.

J. Clin. Invest. 125(2) , 831-45, (2015)

Expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR) causes neuromuscular degeneration in individuals with spinobulbar muscular atrophy (SBMA). PolyQ AR has diminished transc...

Synonyms

N-ethylmaleimide

EINECS 204-892-4

1H-Pyrrole-2,5-dione, 1-ethyl-

n-ethyl-maleimid

MFCD00005509

1-ethylmaleimide

N-ethyl-maleimide

N-ethylmaleic imide

ethvlmaleimide

n-ethvlmaleimide

1-Ethyl-1H-pyrrole-2,5-dione

N-Ethylmaleinimid

Ethylmaleimide

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