CAS 67-42-5|EGTA
Introduction：Basic information about CAS 67-42-5|EGTA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | EGTA | ||
|---|---|---|---|
| CAS Number | 67-42-5 | Molecular Weight | 380.348 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 678.0±55.0 °C at 760 mmHg |
| Molecular Formula | C14H24N2O10 | Melting Point | 241 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 363.9±31.5 °C |
Names
| Name | ethylene glycol bis(2-aminoethyl)tetraacetic acid |
|---|---|
| Synonym | More Synonyms |
EGTA BiologicalActivity
| Description | EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibited the substrate adherence capacity of inflammatory macrophages[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| In Vitro | EGTA, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules[2]. |
| References | [1]. Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426 [2]. Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29(3):211-213. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 678.0±55.0 °C at 760 mmHg |
| Melting Point | 241 °C (dec.)(lit.) |
| Molecular Formula | C14H24N2O10 |
| Molecular Weight | 380.348 |
| Flash Point | 363.9±31.5 °C |
| Exact Mass | 380.143097 |
| PSA | 174.14000 |
| LogP | -2.53 |
| Vapour Pressure | 0.0±4.5 mmHg at 25°C |
| Index of Refraction | 1.547 |
| InChIKey | DEFVIWRASFVYLL-UHFFFAOYSA-N |
| SMILES | O=C(O)CN(CCOCCOCCN(CC(=O)O)CC(=O)O)CC(=O)O |
| Storage condition | Store at RT. |
| Water Solubility | slightly soluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3587 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,807,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84753 No. of Facilities: 111 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 664 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84753 No. of Facilities: 103 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 1556 (estimated) No. of Female Employees: 1043 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | AH3760000 |
| HS Code | 29225000 |
Customs
| HS Code | 29225000 |
|---|
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Synonyms
| Egtazic acid |
| ethylene glycol bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid |
| Egtazic |
| 4F 4PP oxalate |
| CHEL-DE |
| Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid |
| EGTA |
| AEGT |
| ethylene glycol bis(2-aminoethyl)tetraacetic acid |
| (Ethylenebis(oxyethylenenitrilo))tetraacetic acid |
| Ethylene glycol bis(2-aminoethyl ether)tetraacetic acid |
| EINECS 200-651-2 |
| Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid |
| Ethylenebis(oxyethylenenitrilo)tetraacetic acid |
| MFCD00004291 |
| 3,12-Bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioic acid |
| chel tm-de |
| GIETA |
| [ethylenebis(oxyethylenenitrilo)]tetraacetic acid |
| 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)- |
| GEDTA |
| ebonta |
| 3,6-dioxaoctamethylenedinitrilotetraacetic acid |
