CAS 75621-03-3|CHAPS
| Common Name | CHAPS | ||
|---|---|---|---|
| CAS Number | 75621-03-3 | Molecular Weight | 614.877 |
| Density | 1.01 g/mL at 20ºC | Boiling Point | / |
| Molecular Formula | C32H58N2O7S | Melting Point | 156-158ºC |
| MSDS | Chinese | Flash Point | / |
Names
| Name | 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate |
|---|---|
| Synonym | More Synonyms |
CHAPS BiologicalActivity
| Description | CHAPS is a zwitterionic nondenaturing detergent for solubilizing membrane proteins. Target: CHAPS is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons.CHAPS detergent is non-denaturing to membrane proteins, can solubilize proteins, disaggregate protein-protein interactions and is electrically neutral. CHAPS is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12. The critical micelle concentration of CHAPS is 6-10mM. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Others |
| References | [1]. Ofri D, Ritter AM, Liu YF et al. Characterization of solubilized opioid receptors: reconstitution and uncoupling of guanine nucleotide-sensitive agonist binding. J Neurochem. 1992 Feb;58(2):628-35. [2]. Banerjee P, Joo JB, Buse JT, Dawson G. Differential solubilization of lipids along with membrane proteins by different classes of detergents. Chem Phys Lipids. 1995 Aug 1;77(1):65-78. [3]. Pasquali C, Fialka I, Huber LA. Preparative two-dimensional gel electrophoresis of membrane proteins. Electrophoresis. 1997 Dec;18(14):2573-81. [4]. Menshikova I, Menshikov E, Filenko N, Lyubchenko YL. Nucleosomes structure and dynamics: effect of CHAPS. Int J Biochem Mol Biol. 2011;2(2):129-137. [5]. Krofli? A, Sarac B, Be?ter-Roga? M. Thermodynamic characterization of 3-[(3-cholamidopropyl)-dimethylammonium]-1-propanesulfonate (CHAPS) micellization using isothermal titration calorimetry: temperature, salt, and pH dependence. Langmuir. 2012 Jul 17;28( |
Chemical & Physical Properties
| Density | 1.01 g/mL at 20ºC |
|---|---|
| Melting Point | 156-158ºC |
| Molecular Formula | C32H58N2O7S |
| Molecular Weight | 614.877 |
| Exact Mass | 614.396484 |
| PSA | 155.37000 |
| LogP | -4.32 |
| Index of Refraction | 1.6900 (estimate) |
| InChIKey | UMCMPZBLKLEWAF-BCTGSCMUSA-N |
| SMILES | CC(CCC(=O)NCCC[N+](C)(C)CCCS(=O)(=O)[O-])C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C |
| Storage condition | 2-8°C |
| Stability | Moisture Sensitive: Hydroscopic |
| Water Solubility | H2O: 50 mg/mL at 20 °C, clear, colorless | Soluble in water (10 mg/ml). Soluble in DMF and hot methanol. |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 3-[Dimethyl(3-{[(3α,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}propyl)ammonio]propane-1-sulfonate |
| CHAPS,HighPurity |
| 3-[Dimethyl(3-{[(3α,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}propyl)ammonio]-1-propanesulfonate |
| 1-Propanaminium, N,N-dimethyl-3-sulfo-N-[3-[[(3α,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]propyl]-, inner salt |
| 3-{Dimethyl[3-({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl}amino)propyl]ammonio}-1-propanesulfonate |
| CHAPS Solution |
| CHAPS ELECTROPHORESIS REAGENT |
| 1-Propanaminium, N,N-dimethyl-3-sulfo-N-[3-[[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]propyl]-, inner salt |
| MFCD00012116 |
| CHAPS-SOL GRADE |
| 3-[Dimethyl(3-{[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}propyl)ammonio]-1-propanesulfonate |
| CHAPS |
| 3-[Dimethyl(3-{[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}propyl)ammonio]propan-1-sulfonat |
| 1-Propanaminium, N,N-dimethyl-3-sulfo-N-[3-[[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]propyl]-, inner salt |
| 3-[Dimethyl(3-{[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}propyl)ammonio]-1-propanesulfonate |
| 3-[Dimethyl(3-{[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}propyl)ammonio]propane-1-sulfonate |
| CHAPS extrapure |
| TREND |
| N,N-Dimethyl-N-(3-sulfopropyl)-3-[[(3a,5b,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-1-propanaminium Hydroxide Inner Salt |
