CAS 152-72-7|acenocoumarol

Introduction：Basic information about CAS 152-72-7|acenocoumarol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. acenocoumarol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles40
8. Synonyms

Common Name	acenocoumarol
CAS Number	152-72-7	Molecular Weight	353.326
Density	1.4±0.1 g/cm3	Boiling Point	592.7±50.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₅NO₆	Melting Point	196-199ºC
MSDS	ChineseUSA	Flash Point	312.3±30.1 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	acenocoumarol
Synonym	More Synonyms

acenocoumarol BiologicalActivity

Description	Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular Disease

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	592.7±50.0 °C at 760 mmHg
Melting Point	196-199ºC
Molecular Formula	C₁₉H₁₅NO₆
Molecular Weight	353.326
Flash Point	312.3±30.1 °C
Exact Mass	353.089935
PSA	113.33000
LogP	3.15
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.656
Water Solubility	DMSO, heptane and xylene: ≥17mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN4900000

CHEMICAL NAME :: Coumarin, 3-(alpha-acetonyl-p-nitrobenzyl)-4-hydroxy-

CAS REGISTRY NUMBER :: 152-72-7

LAST UPDATED :: 199504

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H15-N-O6

MOLECULAR WEIGHT :: 353.35

WISWESSER LINE NOTATION :: T66 BOVJ DY1V1&R DNW& EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 513 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,3,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 11,85,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 115 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,6,1989 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 24 mg/kg

SEX/DURATION :: female 1-28 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: AFPEAM Archives Francaises de Pediatrie. (Doin Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1942- Volume(issue)/page/year: 36,63,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7380 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 239 (estimated) No. of Female Employees: 157 (estimated)

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P301 + P312 + P330-P305 + P351 + P338
Hazard Codes	Xn
Risk Phrases	63-22-36/37/38
Safety Phrases	26-36/37
RIDADR	UN 2811
RTECS	GN4900000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2932209090

Customs

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles40

A chiral separation strategy for acidic drugs in capillary electrochromatography using both chlorinated and nonchlorinated polysaccharide-based selectors.

Electrophoresis 35(19) , 2807-18, (2014)

A generic chiral separation strategy for the analysis of acidic compounds in CEC is proposed in completion of an earlier defined strategy for nonacidic compounds. The screening step of this strategy u...

A rapid method for determination of 22 selected drugs in human urine by UHPLC/MS/MS for clinical application.

J. AOAC Int. 97(6) , 1526-37, (2015)

A rapid and sensitive ultra-HPLC/MSIMS (UHPLC/MSIMS) assay method for the simultaneous determination in human urine of 22 drugs belonging to different pharmaceutical groups was developed. The drugs we...

Prophylaxis of experimental endocarditis with antiplatelet and antithrombin agents: a role for long-term prevention of infective endocarditis in humans?

J. Infect. Dis. 211(1) , 72-9, (2014)

Infective endocarditis (IE) mostly occurs after spontaneous low-grade bacteremia. Thus, IE cannot be prevented by circumstantial antibiotic prophylaxis. Platelet activation following bacterial-fibrino...

Synonyms

UNII:I6WP63U32H

4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one

Trombostop

EINECS 205-807-3

MFCD00137816

2H-1-Benzopyran-2-one, 4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-

2H-1-Benzopyran-2-one, 4-hydroxy-3-(1-(4-nitrophenyl)-3-oxobutyl)-

2H-1-Benzopyran-2-one, 4-hydroxy-3-(1-(4-nitrophenyl)-3-oxobutyl)-, (±)-

3-(a-Acetonyl-p-nitrobenzyl)-4-hydroxycoumarin

4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one

acenocoumarol

3-(a-p-Nitrophenyl-b-acetylethyl)-4-hydroxycoumarin

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