CAS 35231-44-8|4-(Bromomethyl)-7-methoxy-2H-chromen-2-one

Introduction：Basic information about CAS 35231-44-8|4-(Bromomethyl)-7-methoxy-2H-chromen-2-one, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles83
7. Synonyms

Common Name	4-(Bromomethyl)-7-methoxy-2H-chromen-2-one
CAS Number	35231-44-8	Molecular Weight	269.091
Density	1.6±0.1 g/cm3	Boiling Point	385.3±42.0 °C at 760 mmHg
Molecular Formula	C₁₁H₉BrO₃	Melting Point	213-215 °C(lit.)
MSDS	ChineseUSA	Flash Point	186.8±27.9 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	4-Bromomethyl-7-methoxycoumarin
Synonym	More Synonyms

BiologicalActivity

Description	Br-Mmc (4-Bromomethyl-7-methoxycoumarin) is often used as fluorescent label for the determination of compounds possessing a carboxylic group. Br-Mmc is used for the determination fatty acids by TLC or HPLC[1][2][3].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Wolf JH, et al. 4-Bromomethyl-7-methoxycoumarin and analogues as derivatization agents for high-performance liquid chromatography determinations: a review. J Pharm Biomed Anal. 1992 Feb-Mar;10(2-3):99-107. [2]. Wang K, et al. Derivatization of 5-fluorouracil with 4-bromomethyl-7-methoxycoumarin for determination by liquid chromatography-mass spectrometry. J Am Soc Mass Spectrom. 1998 Sep;9(9):970-6. [3]. Hagen V, et al. Synthesis, photochemistry and application of (7-methoxycoumarin-4-yl)methyl-caged 8-bromoadenosine cyclic 3',5'-monophosphate and 8-bromoguanosine cyclic 3',5'-monophosphate photolyzed in the nanosecond time region. J Photochem Photobiol B. 1999 Nov-Dec;53(1-3):91-102.

Description

Br-Mmc (4-Bromomethyl-7-methoxycoumarin) is often used as fluorescent label for the determination of compounds possessing a carboxylic group. Br-Mmc is used for the determination fatty acids by TLC or HPLC[1][2][3].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Wolf JH, et al. 4-Bromomethyl-7-methoxycoumarin and analogues as derivatization agents for high-performance liquid chromatography determinations: a review. J Pharm Biomed Anal. 1992 Feb-Mar;10(2-3):99-107.

[2]. Wang K, et al. Derivatization of 5-fluorouracil with 4-bromomethyl-7-methoxycoumarin for determination by liquid chromatography-mass spectrometry. J Am Soc Mass Spectrom. 1998 Sep;9(9):970-6.

[3]. Hagen V, et al. Synthesis, photochemistry and application of (7-methoxycoumarin-4-yl)methyl-caged 8-bromoadenosine cyclic 3',5'-monophosphate and 8-bromoguanosine cyclic 3',5'-monophosphate photolyzed in the nanosecond time region. J Photochem Photobiol B. 1999 Nov-Dec;53(1-3):91-102.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	385.3±42.0 °C at 760 mmHg
Melting Point	213-215 °C(lit.)
Molecular Formula	C₁₁H₉BrO₃
Molecular Weight	269.091
Flash Point	186.8±27.9 °C
Exact Mass	267.973511
PSA	39.44000
LogP	2.73
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.595
InChIKey	CTENSLORRMFPDH-UHFFFAOYSA-N
SMILES	COc1ccc2c(CBr)cc(=O)oc2c1
Storage condition	2-8°C
Stability	Stable, but moisture and light-sensitive. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	insoluble

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	1759
WGK Germany	3
Packaging Group	III
Hazard Class	8
HS Code	2932209090

Customs

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles83

Predicting response to vascular endothelial growth factor inhibitor and chemotherapy in metastatic colorectal cancer.

BMC Cancer 14 , 887, (2014)

Bevacizumab improves progression free survival (PFS) and overall survival (OS) in metastatic colorectal cancer patients however currently there are no biomarkers that predict response to this treatmen...

Characterization of adipose tissue-derived stromal vascular fraction for clinical application to cartilage regeneration.

In Vitro Cell. Dev. Biol. Anim. 51(2) , 142-50, (2015)

Bone marrow concentration (BMC) is the most recognized procedure to prepare mesenchymal stem cells for cartilage regeneration. However, bone marrow aspiration is highly invasive and results in low ste...

Effect of codon adaptation on codon-level and gene-level translation efficiency in vivo.

BMC Genomics 15 , 1115, (2014)

There is a significant difference between synonymous codon usage in many organisms, and it is known that codons used more frequently generally showed efficient decoding rate. At the gene level, howeve...

Synonyms

(4-BroMoMethyl-7-MethoxycouMarin)

EINECS 252-448-3

7-methoxy-4-bromomethyl-2H-chromen-2-one

4-bromomethyl-7-methoxy-chromen-2-one

2H-1-Benzopyran-2-one, 4-(bromomethyl)-7-methoxy-

4-Bromomethyl-7-methoxycoumain

7-Methoxy-4-bromomethylcoumarin

4-BROMOETHYL-7-METHOXYCOUMARIN

4-(Bromomethyl)-7-methoxycoumarin

4-bromomethyl-7-hydroxycoumarin

MFCD00006869

BMC

BMC,Br-Mmc

4-(Bromomethyl)-7-methoxy-2H-chromen-2-one

Br-MMc

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