CAS 14769-73-4|(S)-(-)-Levamisole

Introduction：Basic information about CAS 14769-73-4|(S)-(-)-Levamisole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (S)-(-)-Levamisole BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	(S)-(-)-Levamisole
CAS Number	14769-73-4	Molecular Weight	204.291
Density	1.3±0.1 g/cm3	Boiling Point	344.4±45.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₂N₂S	Melting Point	230 - 233ºC
MSDS	/	Flash Point	162.1±28.7 °C

Names

Name	levamisole
Synonym	More Synonyms

(S)-(-)-Levamisole BiologicalActivity

Description	(S)-(-)-Levamisole (Levamisole), an anthelmintic agent with immunomodulatory properties. (S)-(-)-Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC50=300 μM) and α3β4 (EC50=100 μM) subtype of nAChRs. Orally active[1][2].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Membrane Transporter/Ion Channel >>nAChRSignaling Pathways >>Neuronal Signaling >>nAChRResearch Areas >>Inflammation/Immunology
In Vivo	(S)-(-)-Levamisole (Levamisole) (50 μg/ml and 200 μg/ml; p.o.; 30 days) prevents weight gain in mice that were fed a high fat diet[2].
References	[1]. Lewis JA, et al. Levamisole: A Positive Allosteric Modulator for the α3β4 Nicotinic Acetylcholine Receptors Prevents Weight Gain in the CD-1 Mice on a High Fat Diet. Curr Pharm Des. 2017;23(12):1869-1872. [2]. Mehta KP, et al. Immunoregulatory treatment for minimal change nephrotic syndrome. Arch Dis Child. 1986;61(2):153-158.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	344.4±45.0 °C at 760 mmHg
Melting Point	230 - 233ºC
Molecular Formula	C₁₁H₁₂N₂S
Molecular Weight	204.291
Flash Point	162.1±28.7 °C
Exact Mass	204.072113
PSA	40.90000
LogP	1.85
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.713
InChIKey	HLFSDGLLUJUHTE-SNVBAGLBSA-N
SMILES	c1ccc(C2CN3CCSC3=N2)cc1
Storage condition	0-6°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ5940000

CHEMICAL NAME :: Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (S)-

CAS REGISTRY NUMBER :: 14769-73-4

LAST UPDATED :: 199512

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C11-H12-N2-S

MOLECULAR WEIGHT :: 204.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Human

DOSE/DURATION :: 2142 ug/kg

REFERENCE :: PTBIAN Pathologie Biologie. (Expansion Scientifique Francaise, 15, rue St. Benoit, F-75278 Paris Cedex 06, France) V.17- 1969- Volume(issue)/page/year: 28,323,1980 *** REVIEWS *** TOXICOLOGY REVIEW PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,407,1979

Safety Information

Hazard Codes	Xi
RIDADR	UN 2811
HS Code	2934999090

Customs

HS Code	2934100090
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Synonyms

MFCD00792481

6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole

Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-

levomysol

L-teramisole

6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole

lepuron

UNII:C8M7RFE4NO

(±)-Tetramisole

dl-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole

6-Phenyl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazole

dl-Tetramisol

LEVAMISOLE BASE

EINECS 238-836-5

Tetramisole

2,3,5,6-Tetrahydro-6-phenyl-imidazo(2,1-b)thiazole

Levamisole

Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-

dl-2,3,5,6-tetrahydro-6-phenylimidazo(2,1-b)thiazole

(±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole

(±)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole

Ketrax

dl-Tetramisole

Nilverm base

Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (±)-

tetramizole

l-tetramisole

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