Introduction：Basic information about CAS 1420-04-8|Niclosamide olamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Niclosamide olamine |
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| CAS Number | 1420-04-8 | Molecular Weight | 386.230 |
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| Density | / | Boiling Point | 155-156 °C |
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| Molecular Formula | C15H15Cl2N3O5 | Melting Point | 91-93 °C(lit.) |
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| MSDS | / | Flash Point | 149 °F |
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Names
| Name | niclosamide-olamine |
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| Synonym | More Synonyms |
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Niclosamide olamine BiologicalActivity
| Description | Niclosamide olamine is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling. |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>STATSignaling Pathways >>JAK/STAT Signaling >>STATSignaling Pathways >>Autophagy >>Autophagy |
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Chemical & Physical Properties
| Boiling Point | 155-156 °C |
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| Melting Point | 91-93 °C(lit.) |
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| Molecular Formula | C15H15Cl2N3O5 |
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| Molecular Weight | 386.230 |
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| Flash Point | 149 °F |
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| Exact Mass | 385.059601 |
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| PSA | 141.40000 |
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| LogP | 4.09340 |
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| InChIKey | XYCDHXSQODHSLG-UHFFFAOYSA-N |
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| SMILES | NCCO.O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O |
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| Stability | Stable. Hydrolyzes in concentrated acidic or basic solutions. |
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| Water Solubility | soluble |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- VN8575000
- CAS REGISTRY NUMBER :
- 1420-04-8
- LAST UPDATED :
- 199607
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C13-H8-Cl2-N2-O4.C2-H7-N-O
- MOLECULAR WEIGHT :
- 388.23
- WISWESSER LINE NOTATION :
- WNR CG DMVR BQ EG &Z2Q
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 3,103,1976/1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,126,1973 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 336600 ug/kg
- SEX/DURATION :
- female 5-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 53,1,1995 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989
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Safety Information
| Safety Phrases | S16-S26-S36/37/39-S45 |
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| RIDADR | UN 1325 4.1/PG 2 |
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| WGK Germany | 3 |
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| Packaging Group | III |
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| Hazard Class | 4.1 |
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Synonyms
| Luomiecide |
| Hl 2448 |
| MFCD01941566 |
| EINECS 215-811-7 |
| Mollutox |
| 2',5-dichloro-4'-nitrosalicylanilide |
| 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide - 1-propanamine (1:1) |
| Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-, compd. with 1-propanamine (1:1) |
| clonitralid |
| Niclosamide ethanolamine salt |
| 2’,5-dichloro-4’-nitrosalicylanilide - 2-aminoethanol (1:1) |
| BAYER73 |
| (2-hydroxyethyl)ammonium 4-chloro-2-[(2-chloro-4-nitroanilino)carbonyl]phenolate |
| BAY-73 |
| 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide—2-aminoethan-1-ol |
| Snanilcide |
| BAYER-6076 |
| Clonitralide |
| NICLOSAMIDEL |
| 5,2'-dichloro-4'-nitro-salicylanilide ethanolamine salt |
| 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compound with 2-aminoethanol (1:1) |
