Introduction：Basic information about CAS 70797-11-4|Cefpiramide acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cefpiramide acid |
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| CAS Number | 70797-11-4 | Molecular Weight | 612.63700 |
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| Density | 1.75 g/cm3 | Boiling Point | / |
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| Molecular Formula | C25H24N8O7S2 | Melting Point | 213-215° (dec) |
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| MSDS | / | Flash Point | / |
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Names
| Name | cefpiramide |
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| Synonym | More Synonyms |
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Cefpiramide acid BiologicalActivity
| Description | Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| Target | Bacterial[1][2] |
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| In Vitro | Cefpiramide (0-2048 µg/mL; 16-18 hours) shows good activity to against most non-fermentative Gram-negative bacilli and Enterococci (32 µg/mL with 97% inhibition)[1]. Cefpiramide (0-2048 µg/mL; 16-18 hours) exhibits high effective to against Pseudomonas aeruginosa with MIC[50] and MIC[90] values of 4 µg/mL and 16 µg/mL separately[1]. Cell Viability Assay[1] Cell Line: 761 bacterial isolates (35 different species of common bacterial pathogens) Concentration: 0-2048 µg/mL Incubation Time: 16-18 hours Result: Showed broad-spectrum antibacterial activity. |
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| In Vivo | Cefpiramide (25 mg/kg; i.v.; once) shows anti-Streptococcus pneumoniae activity in experimental pneumococcal meningitis[2]. Cefpiramide (25 mg/kg; i.v.; once) reduces bacteria in CSF more than 10[4] CFU/ml[2]. Animal Model: New Zealand white male rabbits(2-3 kg)[2]. Dosage: 25 mg/kg Administration: Intravenous injection; once. Result: Anti-Streptococcus pneumoniae. |
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| References | [1]. Barry AL, et al. Cefpiramide: comparative in-vitro activity and beta-lactamase stability. J Antimicrob Chemother. 1985 Sep;16(3):315-25. [2]. Sato K, et al. Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis. Antimicrob Agents Chemother. 1984 Oct;26(4):578-9. |
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Chemical & Physical Properties
| Density | 1.75 g/cm3 |
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| Melting Point | 213-215° (dec) |
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| Molecular Formula | C25H24N8O7S2 |
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| Molecular Weight | 612.63700 |
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| Exact Mass | 612.12100 |
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| PSA | 263.36000 |
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| LogP | 1.04640 |
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| Index of Refraction | 1.821 |
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| InChIKey | PWAUCHMQEXVFJR-PMAPCBKXSA-N |
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| SMILES | Cc1cc(=O)c(C(=O)NC(C(=O)NC2C(=O)N3C(C(=O)O)=C(CSc4nnnn4C)CSC23)c2ccc(O)cc2)c[nH]1 |
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Safety Information
| RIDADR | NONH for all modes of transport |
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| HS Code | 3003201900 |
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Customs
Synonyms
| CEFPIRAMIDE |
| Cefpiramide acid |
