Introduction：Basic information about CAS 87726-17-8|Panipenem, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Panipenem |
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| CAS Number | 87726-17-8 | Molecular Weight | 339.410 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 555.5±60.0 °C at 760 mmHg |
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| Molecular Formula | C15H21N3O4S | Melting Point | / |
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| MSDS | / | Flash Point | 289.7±32.9 °C |
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Names
| Name | Panipenem |
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| Synonym | More Synonyms |
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Panipenem BiologicalActivity
| Description | Panipenem (PAPM; CS533; RS533) is a carbapenem antibiotic with broad spectrum and potent activity against both Gram-positive and Gram-negative bacteria[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vivo | Panipenem ( 50 mg/kg,i.v.) 在没有胆管插管的雄性 Wistar 大鼠中降低了血浆中 VPA 的浓度，相应的 AUC 也降低了约 20%，同时也会降低血浆中双氯芬酸的浓度[1]。 |
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| References | [1]. S Kojima, et al. Possible mechanism by which the carbapenem antibiotic panipenem decreases the concentration of valproic acid in plasma in rats. Antimicrob Agents Chemother. 1998 Dec;42(12):3136-40. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 555.5±60.0 °C at 760 mmHg |
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| Molecular Formula | C15H21N3O4S |
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| Molecular Weight | 339.410 |
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| Flash Point | 289.7±32.9 °C |
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| Exact Mass | 339.125275 |
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| PSA | 130.23000 |
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| LogP | -3.69 |
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| Vapour Pressure | 0.0±3.4 mmHg at 25°C |
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| Index of Refraction | 1.746 |
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| InChIKey | TYMABNNERDVXID-DLYFRVTGSA-N |
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| SMILES | CC(=N)N1CCC(SC2=C(C(=O)O)N3C(=O)C(C(C)O)C3C2)C1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CL5446511
- CHEMICAL NAME :
- 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-3-((1-(1-iminoethyl)- 3-pyrrolidinyl)thio)-7-oxo-, (5R-(3(S*),5-alpha,6-alpha(R*)))-
- CAS REGISTRY NUMBER :
- 87726-17-8
- LAST UPDATED :
- 199312
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C15-H21-N3-O4-S
- MOLECULAR WEIGHT :
- 339.45
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1300 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 39(Suppl 3),140,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 81 gm/kg/90D-I
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Related to Chronic Data - death
- REFERENCE :
- NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 39(Suppl 3),144,1991
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Synonyms
| (5R,6S)-3-{[(3S)-1-Ethanimidoyl-3-pyrrolidinyl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| (5R,6S)-3-{[(3S)-1-Ethanimidoylpyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-3-[[(3S)-1-(1-iminoethyl)-3-pyrrolidinyl]thio]-7-oxo-, (5R,6S)- |
| (5R,6S)-6-[(R)-1-Hydroxyethyl]-2-[(S)-1-acetimidoylpyrrolidin-3-ylthio]-1-carbapen-2-em-3-carboxylic Acid |
| PAPM |
| cs533 |
| carbapenemrs-533 |
| MFCD00865098 |
| FAROPENEM |
| [5R-[3(S*),5a,6a(R*)]]-6-(1-Hydroxyethyl)-3-[[1-(1-iminoethyl)-3-pyrrolidinyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid |
| Panipenan |
| (+)-(5R,6S)-3-[[(S)-1-Acetimidoyl-3-pyrrolidinyl]thio]-6-[(R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid |
| Panipenem |
