CAS 915-67-3|Amaranth

Introduction：Basic information about CAS 915-67-3|Amaranth, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Amaranth BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Articles25
7. Synonyms

Common Name	Amaranth
CAS Number	915-67-3	Molecular Weight	604.473
Density	1.5	Boiling Point	/
Molecular Formula	C₂₀H₁₁N₂Na₃O₁₀S₃	Melting Point	>300°C
MSDS	USA	Flash Point	44ºC

Names

Name	Acid Red 27
Synonym	More Synonyms

Amaranth BiologicalActivity

Description	Amaranth is a dark red to purple azo dye used as a food dye and to color cosmetics. Amaranth is an anionic dye. It can be applied to natural and synthetic fibers, leather, paper, and phenol-formaldehyde resins.
Related Catalog	Signaling Pathways >>Others >>OthersDye ReagentsResearch Areas >>Others

Chemical & Physical Properties

Density	1.5
Melting Point	>300°C
Molecular Formula	C₂₀H₁₁N₂Na₃O₁₀S₃
Molecular Weight	604.473
Flash Point	44ºC
Exact Mass	603.926880
PSA	241.69000
LogP	6.06870
InChIKey	WLDHEUZGFKACJH-UHFFFAOYSA-K
SMILES	O=S(=O)([O-])c1ccc2c(N=Nc3ccc(S(=O)(=O)[O-])c4ccccc34)c(O)c(S(=O)(=O)[O-])cc2c1.[Na+].[Na+].[Na+]
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	50 g/L (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ6550000

CHEMICAL NAME :: 2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((4-sulfo-1-naphthyl)azo)-, trisodium salt

CAS REGISTRY NUMBER :: 915-67-3

LAST UPDATED :: 199709

DATA ITEMS CITED :: 36

MOLECULAR FORMULA :: C20-H11-N2-O10-S3.3Na

MOLECULAR WEIGHT :: 604.48

WISWESSER LINE NOTATION :: L66J BSWQ ENUN- BL66J CQ DSWQ HSWQ &-NA- 3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 96550 ug/kg/28D-C

TOXIC EFFECTS :: Liver - changes in liver weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 680 gm/kg/14W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1643 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 548 mg/kg

SEX/DURATION :: female 52 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 547 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 33 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 65 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 296 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 548 mg/kg

SEX/DURATION :: male 52 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3528 ug/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4550 uL/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 2 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4900 uL/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 12 mL/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 4 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 250 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 16500 ug/kg

SEX/DURATION :: female 6-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 100 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 2 gm/L

REFERENCE :: GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,41,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,41,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 14,127,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2137 No. of Facilities: 1931 (estimated) No. of Industries: 9 No. of Occupations: 12 No. of Employees: 13075 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2137 No. of Facilities: 2272 (estimated) No. of Industries: 12 No. of Occupations: 22 No. of Employees: 13792 (estimated) No. of Female Employees: 5645 (estimated)

Safety Information

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	36/37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	QJ6550000

Articles25

Evaluation of potential genotoxicity of five food dyes using the somatic mutation and recombination test.

Chemosphere 88(8) , 974-9, (2012)

In this study, different concentrations of five food dyes (amaranth, patent blue, carminic acid, indigotine and erythrosine) have been evaluated for genotoxicity in the Somatic Mutation and Recombinat...

Monoolein cubic phase containing acidic proteinoid: pH-dependent release.

Drug Dev. Ind. Pharm. 37(1) , 56-61, (2011)

Monoolein (MO) cubic phase containing acidic proteinoid was prepared for a pH-dependent release.The acidic proteinoid was prepared by a thermal-condensation reaction of Asp and Leu (9.85/0.15 in molar...

Genotoxicity assessment of amaranth and allura red using Saccharomyces cerevisiae.

Bull. Environ. Contam. Toxicol. 90(1) , 22-6, (2013)

Amaranth (E123) and Allura red (E129), very important food azo dyes used in food, drug, paper, cosmetic and textile industries, were assessed for their genotoxic potential through comet assay in yeast...

Synonyms

Amaranth Extra

Trisodium 3-hydroxy-4-[(4-sulfonato-1-naphthyl)diazenyl]-2,7-naphthalenedisulfonate

hidacid amaranth

l-rot3

FD & C Red No. 2

maple amaranth

Red dye No. 2

amaranth bpc

red no. 2

S-azo rubine

CI Food Red 9

Amaranth red

Rouge Solid E

C.I. food red 9

lissamine amaranth ac

takaoka amaranth

Trisodium 3-hydroxy-4-[(E)-(4-sulfonato-1-naphthyl)diazenyl]naphthalene-2,7-disulfonate

azo rubine sf

edicol amaranth

Amacid Amaranth

amaranth lake

3-Hydroxy-4-[(4-sulfo-1-naphthalenyl)azo]-2,7-naphthalenedisulfonic Acid Trisodium Salt

bordeaux s

2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((4-sulfo-1-naphthalenyl)azo)-, trisodium salt

edicol supra amaranth a

naphthol red s

Naphthol Red S Specially Pure

Japan Red No. 2

Japan Food Red No. 2

hexacol amaranth b extra

amaranth wd

1508 red

tertracid red a

trisodium salt of 1-(4-sulfo-1-naphthylazo)-2-naphthol-3,6-disulfonic acid

certicol amaranth s

aizen amaranth

Food Red No. 2

amaranth a

hd amaranth supra

hd amaranth b

Canacert Amaranth

D&C Red No. 2

acid amaranth i

Trisodium 3-hydroxy-4-[(E)-(4-sulfonato-1-naphthyl)diazenyl]-2,7-naphthalenedisulfonate

hexacert red no. 2

Amaranth

Amaranth USP

MFCD00004076

EINECS 213-022-2

acid amaranth n

kiton rubine s

Amaranth R

azo red r

kayaku food colour red no. 2

INS 123

Amaranth S Specially Pure

Cranberry Red

shikiso amaranth

trisodium 2-hydroxy-1-(4-sulfonato-1-naphthylazo)naphthalene-3,6-disulfonate

amaranth s

dolkwal amaranth

1-(4-sulfo-1-naphthylazo)-2-naphthol-3,6-disulfonic acid trisodium salt

san-ei amaranth

kayaku amaranth

trisodium 3-hydroxy-4-[(E)-(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2,7-disulfonate

amaranth b

toyo amaranth

Dye Red Raspberry

amarant

L Red Z 3050

1508red

1302 red

neklacid red a

acid leather rubine s

Naphthol Red S Conc. Specially Pure

Acid Amaranth J

2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((4-sulfo-1-naphthyl)azo)-, trisodium salt

azo ruby s

Hidacid Amaranth 21-6008

1302red

fruit red a geigy

eurocert amaranth

3-Hydroxy-4-((4-sulfo-1-naphthalenyl)azo)-2,7-naphthalenedisulfonic acid trisodium salt

redno.2

Azo Rubine S-FQ

rakuto amaranth

FD and Red No. 2

java amaranth

hispacid red am

L Red 3

naphthol red LZS

2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-[(E)-2-(4-sulfo-1-naphthalenyl)diazenyl]-, sodium salt (1:3)

Naphthol Red SI

solar red o

2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-[(4-sulfo-1-naphthyl)azo]-, trisodium salt

Japan Red 2

kca foodcol amaranth a

azoredr

E123

C.I. Acid Red 27

Amaranth 85

FAST RED

2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-[2-(4-sulfo-1-naphthalenyl)diazenyl]-, sodium salt (1:3)

acid amaranth

daishiki amaranth

azorubin s

c.i.184

Edicol Supra Amaranth AS

Acid Leather Red I 2BW

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