CAS 5108-96-3|Ammonium 1-pyrrolidinedithiocarbamate
Introduction：Basic information about CAS 5108-96-3|Ammonium 1-pyrrolidinedithiocarbamate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ammonium 1-pyrrolidinedithiocarbamate | ||
|---|---|---|---|
| CAS Number | 5108-96-3 | Molecular Weight | 164.292 |
| Density | 1.264g/cm3 | Boiling Point | 199.7ºC at 760 mmHg |
| Molecular Formula | C5H12N2S2 | Melting Point | 153-155 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 74.6ºC |
Names
| Name | Ammonium 1-pyrrolidinedithiocarbamate |
|---|---|
| Synonym | More Synonyms |
Ammonium 1-pyrrolidinedithiocarbamate BiologicalActivity
| Description | Pyrrolidinedithiocarbamate ammonium is a selective NF-κB inhibitor. |
|---|---|
| Related Catalog | Signaling Pathways >>NF-κB >>NF-κBResearch Areas >>Cancer |
| Target | NF-κB |
| In Vitro | Pretreatment of cells with pyrrolidinedithiocarbamate (3-1000 μM) dose-dependently attenuate IL-8 production. Furthermore, pyrrolidinedithiocarbamate (100 μM) suppresses the accumulation of IL-8 mRNA. Pyrrolidinedithiocarbamate inhibits the activation of NF-κB, because pyrrolidinedithiocarbamate suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate decrease IL-8 production by intestinal epithelial cells[1]. |
| In Vivo | The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis[2]. |
| Cell Assay | The human colon cancer cell line HT-29 is obtained and cells are grown in modified McCoy’s 5A medium supplemented with 10% fetal bovine serum. To study the effect of pyrrolidinedithiocarbamate ammonium on IL-8 production, HT-29 cells in 96-well plates are induced with 20 ng/mL of IL-1β for 18 h. Various concentrations (3-1000 μM) of pyrrolidinedithiocarbamate or its vehicle (culture medium) are added to the cells 30 min prior to IL-1β stimulation. The concentration of IL-8 in the supernatant is determined using solid-phase enzyme-linked immunosorbent assay[1]. |
| Animal Admin | Animal Administration: [2]Pyrrolidinedithiocarbamate is administered intraperitoneally to mice at dose levels of 100 and 50 mg/kg. Mice are divided into a DSS-untreated group (normal group), DSS-treated control group, DSS+pyrrolidinedithiocarbamate-treated groupI (low-dose group), and DSS+pyrrolidinedithiocarbamate-treated groupII (high-dose group). In each group, the disease activity index score (DAI score), intestinal length, histological score, and the levels of activated NF-κB and inflammatory cytokines (IL-1β and TNF-α) in tissue are measured[2]. |
| References | [1]. Németh ZH, et al. Pyrrolidinedithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells. Immunol Lett. 2003 Jan 2;85(1):41-6. [2]. Qin JD, et al. Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and CYP2E1 content of rats with immunological liver injury. Pharm Biol. 2014 Nov;52(11):1460-1466. |
Chemical & Physical Properties
| Density | 1.264g/cm3 |
|---|---|
| Boiling Point | 199.7ºC at 760 mmHg |
| Melting Point | 153-155 °C(lit.) |
| Molecular Formula | C5H12N2S2 |
| Molecular Weight | 164.292 |
| Flash Point | 74.6ºC |
| Exact Mass | 164.044189 |
| PSA | 77.37000 |
| LogP | 1.55870 |
| InChIKey | VSWDORGPIHIGNW-UHFFFAOYSA-M |
| SMILES | S=C([S-])N1CCCC1 |
| Storage condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Water Solubility | 50 g/L (20 ºC) |
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S36-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 29339990 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-Pyrrolidinecarbodithioic acid,ammonium salt |
| EINECS 225-834-4 |
| Pyrrolindinedithiocarbamate ammonium |
| 1-Pyrrolidinecarbodithioic acid ammoniate (1:1) |
| Ammonium Pyrrolidine-N-dithiocarbamate |
| ammonium tetramethylenedithiocarbamate |
| Pyrrolidine-N-dithiocarbamic Acid Ammonium Salt |
| Ammonium 1-pyrrolidinedithiocarboxylate |
| APDTC AMMONIUM SALT |
| Ammonium pyrrolidinecarbodithioate |
| MFCD00012720 |
| APCD |
| PDTC,NH4 |
| PYRROLIDINEDITHIOCARBAMATE |
| APDTC |
| 1-PYRROLIDINECARBODITHIOIC ACID AMMONIUM SALT |
| QX 314 chloride |
| pyrrolidine-1-dithiocarboxylic acid ammonium salt |
| Ammonium pyrrolidine |
| 1-Pyrrolidinecarbodithioic acid, ammonuim salt |
| Ammonium pyrrolidine dithiocarbamate |
| Pyrrolidinedithiocarbamic acid ammonium salt |
| APDC |
| Ammonium 1-Pyrrolidinecarbodithioate |
| 1-PYRROLIDINECARBODITHIOIC ACID |
| Pyrrolidinedithiocarbamate ammonium |
| APDC AMMONIUM SALT |
| Ammonium 1-pyrrolidinedithiocarbamate |
| Ammoniumpyrrolidinedithiocarb |
| Ammonium pyrrolidine-1-carbodithioate |
| 1-Pyrrolidinecarbodithioic acid, ammonium salt |
| 1-Pyrrolidinecarbodithioic acid ammonium salt,APDC,Ammonium pyrrolidinecarbodithioate |
| Ammonium pyrrolidinedithiocarbamate |
| Pyrrolidinedithiocarbamate (ammonium) |
