CAS 128340-47-6|HIV Protease Substrate IV
| Common Name | HIV Protease Substrate IV | ||
|---|---|---|---|
| CAS Number | 128340-47-6 | Molecular Weight | 1090.28000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C49H83N15O13 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Lys-Ala-Arg-Val-Nle-p-nitro-Phe-Glu-Ala-Nle amide |
|---|---|
| Synonym | More Synonyms |
HIV Protease Substrate IV BiologicalActivity
| Description | HIV Protease Substrate IV is a substrate of HIV protease. HIV Protease Substrate IV can be used to measure the activity of HIV (human immunodeficiency virus) -1 protease[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Metabolic Enzyme/Protease >>HIV Protease |
| References | [1]. Chaudhury S, et, al. Identification of structural mechanisms of HIV-1 protease specificity using computational peptide docking: implications for drug resistance. Structure. 2009 Dec 9;17(12):1636-1648. |
Chemical & Physical Properties
| Molecular Formula | C49H83N15O13 |
|---|---|
| Molecular Weight | 1090.28000 |
| Exact Mass | 1089.63000 |
| PSA | 472.95000 |
| LogP | 5.10380 |
| InChIKey | MJGGTDHEIUOPEB-WBMHOGBOSA-N |
| SMILES | CCCCC(NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(Cc1ccc([N+](=O)[O-])cc1)NC(=O)C(CCCC)NC(=O)C(NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(N)CCCCN)C(C)C)C(N)=O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles5
More Articles| Characterization of the murine leukemia virus protease and its comparison with the human immunodeficiency virus type 1 protease. J. Gen. Virol. 87(Pt 5) , 1321-30, (2006) The protease (PR) of Murine leukemia virus (MLV) was expressed in Escherichia coli, purified to homogeneity and characterized by using various assay methods, including HPLC-based, photometric and fluo... | |
| Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs. FEBS J. 272(20) , 5265-77, (2005) HIV-1 protease (PR) and two drug-resistant variants--PR with the V82A mutation (PR(V82A)) and PR with the I84V mutation (PR(I84V))--were studied using reduced peptide analogs of five natural cleavage ... | |
| Interactions of a novel inhibitor from an extremophilic Bacillus sp. with HIV-1 protease: implications for the mechanism of inactivation. J. Biol. Chem. 276(4) , 2487-93, (2001) The active site cleft of the HIV-1 protease (PR) is bound by two identical conformationally mobile loops known as flaps, which are important for substrate binding and catalysis. The present article re... |
Synonyms
| HIV Substrate,KARVNleF(4-NO2)EANle-NH2 |
