CAS 114495-97-5|Neuropeptide Y (18-36) trifluoroacetate salt

Introduction：Basic information about CAS 114495-97-5|Neuropeptide Y (18-36) trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameNeuropeptide Y (18-36) trifluoroacetate salt
CAS Number114495-97-5Molecular Weight2456.80000
Density/Boiling Point/
Molecular FormulaC112H174N36O27Melting Point/
MSDS/Flash Point/

Names

NameNeuropeptide Y (18-36), porcine

BiologicalActivity

DescriptionNeuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to rat cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure[1].
Related CatalogResearch Areas >>Cardiovascular DiseaseResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neuropeptide Y Receptor
Target

IC50: 158 nM (I-NPY); Ki: 140 nM (I-NPY)[1]

In VitroNeuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to rat cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM[1]. Neuropeptide Y (18-36) (porcine) (1 μM) shifts the inhibitory adenylate cyclase activity dose-response curve of NPY to the right in a parallel fashion[1]. Neuropeptide Y (18-36) (porcine) (1 μM) completely abolishes the effect of NPY (10 nM) that alone caused 80% of the maximum inhibition of adenylate cyclase activity[1].
References

[1]. A Balasubramaniam, et al. Neuropeptide Y (18-36) is a competitive antagonist of neuropeptide Y in rat cardiac ventricular membranes. J Biol Chem. 1990 Sep 5;265(25):14724-7.

Chemical & Physical Properties

Molecular FormulaC112H174N36O27
Molecular Weight2456.80000
Exact Mass2455.33000
PSA1076.75000
LogP5.67680
InChIKeyKPPFDQVOSMXZBV-VMRDKNQRSA-N
SMILESCCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)N)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccc(O)cc1)C(N)=O)C(C)O)C(C)CC
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