Introduction：Basic information about CAS 153049-49-1|PD 145065, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | PD 145065 |
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| CAS Number | 153049-49-1 | Molecular Weight | 950.12900 |
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| Density | 1.24g/cm3 | Boiling Point | 1252.1ºC at 760mmHg |
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| Molecular Formula | C52H67N7O10 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
PD 145065 BiologicalActivity
| Description | PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC50 value of 4 nM for the ETA receptor for rabbit renal artery vascular smooth muscle cells[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| References | [1]. Warner TD, et al. Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065. Br J Pharmacol. 1994 May;112(1):207-13. |
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Chemical & Physical Properties
| Density | 1.24g/cm3 |
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| Boiling Point | 1252.1ºC at 760mmHg |
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| Molecular Formula | C52H67N7O10 |
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| Molecular Weight | 950.12900 |
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| Exact Mass | 949.49500 |
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| PSA | 264.99000 |
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| LogP | 6.61280 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.59 |
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| InChIKey | HRAQSWKGRRUBDJ-OMUAVVNCSA-N |
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| SMILES | CCC(C)C(NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)NC(C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O)C(C)CC |
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