CAS 85344-77-0|Pyr-His-Pro-Gly-OH

Introduction：Basic information about CAS 85344-77-0|Pyr-His-Pro-Gly-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Pyr-His-Pro-Gly-OH BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Pyr-His-Pro-Gly-OH
CAS Number	85344-77-0	Molecular Weight	420.42000
Density	1.461g/cm3	Boiling Point	1069.5ºC at 760 mmHg
Molecular Formula	C₁₈H₂₄N₆O₆	Melting Point	/
MSDS	/	Flash Point	600.6ºC

Names

Name	TRH-Gly
Synonym	More Synonyms

Pyr-His-Pro-Gly-OH BiologicalActivity

Description	Trh-gly (TRH-glycine) is a precursor of thyrotropin (TSH)-releasing hormone (TRH) that can release thyrotropin and prolactin[1].
Related Catalog	Research Areas >>EndocrinologySignaling Pathways >>Others >>Thyroid Hormone Receptor
In Vitro	在表达内源性 TRH-R 的 GH3 细胞中，Trh-gly 引起细胞内钙浓度的立即升高，表明 Trh-gly 直接反应而不从 Trh-gly 转化为 TRH[2]。
In Vivo	在聚氨酯麻醉的 2 个月大（250 克）雄性 Sprague-Dawley 大鼠中，Trh-gly（脑池内注射；1.0 mg）导致下丘脑、延髓和血液中的 TRH 水平显着增加[1]。
References	[1]. A E Pekary, et al. Release of thyrotropin and prolactin by a thyrotropin-releasing hormone (TRH) precursor, TRH-Gly: conversion to TRH is sufficient for in vivo effects. Neuroendocrinology. 1990 Dec;52(6):618-25. [2]. M Yamada, et al. Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly. Neurosci Lett. 1995 Aug 18;196(1-2):109-12.

Chemical & Physical Properties

Density	1.461g/cm3
Boiling Point	1069.5ºC at 760 mmHg
Molecular Formula	C₁₈H₂₄N₆O₆
Molecular Weight	420.42000
Flash Point	600.6ºC
Exact Mass	420.17600
PSA	173.59000
Index of Refraction	1.611
InChIKey	CSVCLHYFVGHUCM-AVGNSLFASA-N
SMILES	O=C(O)CNC(=O)C1CCCN1C(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1

Synonyms

PE-H-P-G

PYR-HIS-PRO-GLY-OH

THYROTROPIN-RELEASING HORMONE-GLY

pglu-his-pro-gly

PYR-HIS-PRO-GLY

GLP-HIS-PRO-GLY

Recommended......