CAS 57468-16-3|Substance P(1-4)

Introduction：Basic information about CAS 57468-16-3|Substance P(1-4), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Substance P(1-4) BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Substance P(1-4)
CAS Number	57468-16-3	Molecular Weight	496.60400
Density	/	Boiling Point	/
Molecular Formula	C₂₂H₄₀N₈O₅	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	1-[6-amino-2-[[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid
Synonym	More Synonyms

Substance P(1-4) BiologicalActivity

Description	Substance P(1-4) is a potent neurokinin receptors (NK-R) antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Others >>Others
In Vitro	Substance P(1-4) (0.1 nM-1 μM) inhibits endogenous erythroid colony (EEC) formation in PV bone marrow cultures[1]. Substance P(1-4) (0.1 nM-1 μM; CD36+/GpA- cells) decreases of erythroid colony numbers of 47% and inhibits proliferation of PV CD36+/GpA- cells of 30 %[1]. Cell Viability Assay[1] Cell Line: PV CD36+/GpA- cells Concentration: 0.1 nM-1 μM Incubation Time: 2 days Result: Inhibited proliferation of PV CD36+/GpA- cells of 30 %. Apoptosis Analysis[1] Cell Line: PV CD36+/GpA- cells Concentration: 10 nM Incubation Time: 2 days Result: Increased the percentage of cell death of 27.3%.

Chemical & Physical Properties

Molecular Formula	C₂₂H₄₀N₈O₅
Molecular Weight	496.60400
Exact Mass	496.31200
PSA	220.96000
LogP	1.11560
InChIKey	VTGZBKFUTINRBR-UHFFFAOYSA-N
SMILES	NCCCCC(NC(=O)C1CCCN1C(=O)C(N)CCCN=C(N)N)C(=O)N1CCCC1C(=O)O

Synonyms

Arg-Pro-Lys-Pro

1-(6-amino-2-{[1-(2-amino-5-carbamimidamidopentanoyl)pyrrolidin-2-yl]formamido}hexanoyl)pyrrolidine-2-carboxylic acid

substance P(1-4)

SUBSTANCE P,Fragment 1-4

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