CAS 53749-60-3|Substance P (4-11)

Introduction：Basic information about CAS 53749-60-3|Substance P (4-11), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Substance P (4-11) BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Substance P (4-11)
CAS Number	53749-60-3	Molecular Weight	966.15700
Density	1.266g/cm3	Boiling Point	1470.1ºC at 760mmHg
Molecular Formula	C₄₆H₆₇N₁₁O₁₀S	Melting Point	/
MSDS	/	Flash Point	842.9ºC

Names

Name	Substance P (4-11)/Octa-Substance P
Synonym	More Synonyms

Substance P (4-11) BiologicalActivity

Description	Substance P (4-11), the C-terminus fragment of Substance P (Substance P (HY-P0201)), is a Substance P agonist that shows highly selective for NK1 receptors[1][2].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neurokinin Receptor
In Vitro	Substance P (4-11) 在浓度为 1 nM-100 nM 时显着刺激体外人 T 淋巴细胞的增殖，通过胸苷和亮氨酸的摄取评估[1]。 Substance P (4-11) 在人多形核白细胞 (PMN) 中引发强烈的学发光，具有时间和剂量反应曲线[3]。
References	[1]. D G Payan, et al. Specific stimulation of human T lymphocytes by substance P. J Immunol. 1983 Oct;131(4):1613-5. [2]. L Wang, et al. Substance P induces ion secretion in mouse small intestine through effects on enteric nerves and mast cells. Am J Physiol. 1995 Jul;269(1 Pt 1):G85-92. [3]. P Cornaglia-Ferraris, et al. Sensory neuropeptides (substance P) and 4-11 SP enhance human neutrophils chemiluminescence; the role of L-arginine. Int J Immunopharmacol. 1986;8(4):463-8.

Chemical & Physical Properties

Density	1.266g/cm3
Boiling Point	1470.1ºC at 760mmHg
Molecular Formula	C₄₆H₆₇N₁₁O₁₀S
Molecular Weight	966.15700
Flash Point	842.9ºC
Exact Mass	965.47900
PSA	370.30000
LogP	3.23030
Index of Refraction	1.578
InChIKey	XVTHVTVZLLFSPI-UHFFFAOYSA-N
SMILES	CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1)C(N)=O

Synonyms

PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2

SUBSTANCE P (4-11)

L-Pro-L-Glu(NH2)-L-Glu(NH2)-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2

substance P fragment 4-11 acetate

Substance P,fragment 4-11

OCTA-SUBSTANCE P

SUBSTANCE P(4-11),[D-PRO4,D-TRP7,9]

Substance-P-(4-11)Octa-Substance P

L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2

H-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2

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