Introduction：Basic information about CAS 15686-83-6|pyrante, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | pyrante |
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| CAS Number | 15686-83-6 | Molecular Weight | 594.67700 |
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| Density | 1.13g/cm3 | Boiling Point | 324.4ºC at 760mmHg |
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| Molecular Formula | C34H30N2O6S | Melting Point | 178-179ºC |
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| MSDS | / | Flash Point | 150ºC |
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Names
| Name | pyrantel |
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| Synonym | More Synonyms |
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pyrante BiologicalActivity
| Description | Pyrantel is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Membrane Transporter/Ion Channel >>nAChRSignaling Pathways >>Neuronal Signaling >>nAChR |
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| Target | Parasites[1][2]. |
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| In Vitro | Pyrantel (10 nM-10 µM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity[1][2]. Cell Viability Assay[1] Cell Line: A. suum Concentration: 10 nM-10 µM Incubation Time: 72 h Result: Inhibited A. suum with a pEC50 value of 7.24. Cell Viability Assay[2] Cell Line: N. americanus Concentration: 0-168.2 M (0-100 µg/mL) Incubation Time: 72 h Result: Inhibited third-stage larvae and adult of N. americanus with IC50 values of 2.0 and 7.6 mg/mL, respectively. |
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| In Vivo | Pyrantel (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%[2]. Animal Model: Male Syrian Golden hamsters (3-week-old; A. ceylanicum-infected)[2]. Dosage: 10 mg/kg Administration: Oral administration; single. Result: Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively. |
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Chemical & Physical Properties
| Density | 1.13g/cm3 |
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| Boiling Point | 324.4ºC at 760mmHg |
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| Melting Point | 178-179ºC |
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| Molecular Formula | C34H30N2O6S |
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| Molecular Weight | 594.67700 |
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| Flash Point | 150ºC |
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| Exact Mass | 594.18200 |
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| PSA | 158.90000 |
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| LogP | 6.26020 |
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| Vapour Pressure | 2.13E-17mmHg at 25°C |
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| InChIKey | YSAUAVHXTIETRK-AATRIKPKSA-N |
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| SMILES | CN1CCCN=C1C=Cc1cccs1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UW0248000
- CHEMICAL NAME :
- Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)-, (E)-
- CAS REGISTRY NUMBER :
- 15686-83-6
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C11-H14-N2-S
- MOLECULAR WEIGHT :
- 206.33
- WISWESSER LINE NOTATION :
- T6N CN AUTJ B1U1- BT5SJ& C1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 170 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 175 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ANBCB3 Antibiotics and Chemotherapy (Basel). (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.17- 1971- Volume(issue)/page/year: 30,1,1981
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| pyrante |
| banminth |
| Pyrantel Base |
| 1,4,5,6-Tetrahydro-1-methyl-2-[(E)-2-(2-thienyl)vinyl]pyrimidine |
| PYRANTEL PARMOATE |
| strongid |
| pyrequan |
| 4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)-(e)-pyrimidin |
| 1-methyl-2-(2-thiophen-2-ylvinyl)-1,4,5,6-tetrahydro-pyrimidine |
| PYRANTELUM |
| 1-methyl-2-(trans-2-thiophen-2-yl-vinyl)-1,4,5,6-tetrahydro-pyrimidine |
