CAS 141-05-9|diethylmaleate
Introduction：Basic information about CAS 141-05-9|diethylmaleate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | diethylmaleate | ||
|---|---|---|---|
| CAS Number | 141-05-9 | Molecular Weight | 172.178 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 214.0±0.0 °C at 760 mmHg |
| Molecular Formula | C8H12O4 | Melting Point | −10 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 93.3±0.0 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | diethyl maleate |
|---|---|
| Synonym | More Synonyms |
diethylmaleate BiologicalActivity
| Description | Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. Diethyl maleate (DEM), a thiol-reactive α,β-unsaturated carbonyl compound, depletes glutathione (GSH) in exposed cells[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. Andrea Gille, et al. Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate. Redox Biol. 2019 Jan;20:19-27. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 214.0±0.0 °C at 760 mmHg |
| Melting Point | −10 °C(lit.) |
| Molecular Formula | C8H12O4 |
| Molecular Weight | 172.178 |
| Flash Point | 93.3±0.0 °C |
| Exact Mass | 172.073563 |
| PSA | 52.60000 |
| LogP | 1.68 |
| Vapour density | 5.93 (vs air) |
| Vapour Pressure | 0.2±0.4 mmHg at 25°C |
| Index of Refraction | 1.443 |
| InChIKey | IEPRKVQEAMIZSS-WAYWQWQTSA-N |
| SMILES | CCOC(=O)C=CC(=O)OCC |
| Stability | Stable. Combustible. Incompatible with oxidizing agents, bases, acids, reducing agents. |
| Water Solubility | insoluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3070 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 4 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 8700 nmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 182,135,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 8700 nmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 182,135,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H317-H319-H412 |
| Precautionary Statements | P273-P280-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R43 |
| Safety Phrases | S26-S36/37-S37-S24 |
| RIDADR | 3334 |
| WGK Germany | 2 |
| RTECS | ON1225000 |
| HS Code | 29171990 |
Customs
| HS Code | 2917190090 |
|---|---|
| Summary | 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| cis-Diethyl maleate |
| MFCD00009191 |
| diethyl L-malic ester |
| Diethyl L-(-)-Malate |
| (S)-(-)-Aepfelsaeure-diethylester |
| cis-Propenoic acid diethyl ester |
| Maleic acid, diethyl ester |
| EINECS 205-451-9 |
| (S)-malic acid diethyl ester |
| diethylmaleate |
| 2-Butenedioic acid, diethyl ester, (2Z)- |
| Diethyl (2Z)-2-butenedioate |
| Diethyl (2Z)-but-2-enedioate |
| cis-EtO2CCH=CHCO2Et |
| L-(-)-Malic Acid Diethyl Ester |
| (S)-(-)-diethyl 2-hydroxybutandioate |
| diethyl (Z)-but-2-enedioate |
| diethyl (2Z)but-2-ene-1,4-dioate |
| 1,4-diethyl (2Z)-but-2-enedioate |
| 2-Butenedioic acid (2Z)-, diethyl ester |
| 2-Butenedioic acid (Z)-, diethyl ester |
| maleic acid diethyl ester |
| Ethyl Maleate |
| (2S)-2-hydroxybutanedioic acid diethylester |
| Diethyl maleate |
| diethyl (S)-malate |
| (Z)-2-Butenedioic acid diethyl ester |
| Irsogladine Impurity 3 |
