CAS 5451-09-2|5-Aminolevulinic acid hydrochloride

Introduction：Basic information about CAS 5451-09-2|5-Aminolevulinic acid hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 5-Aminolevulinic acid hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
5. Safety Information
6. Customs
7. Articles63
8. Synonyms

Common Name	5-Aminolevulinic acid hydrochloride
CAS Number	5451-09-2	Molecular Weight	167.59
Density	1.2±0.1 g/cm3	Boiling Point	311.5±27.0 °C at 760 mmHg
Molecular Formula	C₅H₁₀ClNO₃	Melting Point	~150 °C (dec.)
MSDS	ChineseUSA	Flash Point	142.2±23.7 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	5-Aminolevulinic Acid Hydrochloride
Synonym	More Synonyms

5-Aminolevulinic acid hydrochloride BiologicalActivity

Description	5-Aminolevulinic acid HCl is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.Target: Others5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. Median follow-up was 35.4 months (95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore, in the case of functional grade III gliomas, iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique [2].
Related Catalog	Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Autophagy >>MitophagyResearch Areas >>Metabolic DiseaseNatural Products >>Others
References	[1]. Stummer, W., et al., Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol, 2006. 7(5): p. 392-401. [2]. Eyupoglu, I.Y., et al., Improving the extent of malignant glioma resection by dual intraoperative visualization approach. PLoS One, 2012. 7(9): p. e44885.

Description

5-Aminolevulinic acid HCl is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.Target: Others5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. Median follow-up was 35.4 months (95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore, in the case of functional grade III gliomas, iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique [2].

Related Catalog

Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Autophagy >>MitophagyResearch Areas >>Metabolic DiseaseNatural Products >>Others

References

[1]. Stummer, W., et al., Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol, 2006. 7(5): p. 392-401.

[2]. Eyupoglu, I.Y., et al., Improving the extent of malignant glioma resection by dual intraoperative visualization approach. PLoS One, 2012. 7(9): p. e44885.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	311.5±27.0 °C at 760 mmHg
Melting Point	~150 °C (dec.)
Molecular Formula	C₅H₁₀ClNO₃
Molecular Weight	167.59
Flash Point	142.2±23.7 °C
PSA	80.39000
LogP	-0.79
Appearance of Characters	powder
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.482
InChIKey	ZLHFONARZHCSET-UHFFFAOYSA-N
SMILES	Cl.NCC(=O)CCC(=O)O
Storage condition	2-8°C
Water Solubility	H2O: 50 mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OI1640000

CHEMICAL NAME :: Levulinic acid, 5-amino-, hydrochloride (8CI)

CAS REGISTRY NUMBER :: 5451-09-2

LAST UPDATED :: 199304

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C5-H9-N-O3.Cl-H

MOLECULAR WEIGHT :: 167.61

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi,Xn
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin . R66:Repeated exposure may cause skin dryness or cracking. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
Safety Phrases	S26-S36/37-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	OI1640000
HS Code	2922509090

Customs

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles63

Identification and Characterization of EDTA Test Strip Interfering Substances Using a Digital Color Detector.

Clin. Lab. 61 , 785-91, (2015)

Rapid test strips for ethylenediaminetetraacetic acid (EDTA) can be used to verify correct specimen types for clinical assays which require, or cannot be performed on, plasma collection tubes containi...

N-3 fatty acids improve body composition and insulin sensitivity during energy restriction in the rat.

Prostaglandins Leukot. Essent. Fatty Acids 91(5) , 203-11, (2014)

The hypothesis that n-3 polyunsaturated fatty acids (PUFA) could contribute to maintain muscle mass during energy restriction aiming to weight loss was tested in the rat, with special attention paid t...

Determination of free fatty acids in human serum by HPLC with fluorescence detection.

J. Chromatogr. Sci. 53 , 537-41, (2015)

It has been suggested that serum concentrations of polyunsaturated essential fatty acids correlate with the symptoms or severity of various diseases, including depression and Alzheimer-type dementia, ...

Synonyms

5-Aminolevulinic acid hydrochloride

MFCD00012869

EINECS 226-679-5

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